| Exercise-induced increase in lipid peroxidation in patients with chronic heart failure: relation to exercise intolerance. | |
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MedLine Citation:
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PMID: 17290101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Little is known about the relationship between exercise intolerance and lipid peroxidation in chronic heart failure (CHF) patients. This study was designed to investigate the relationship between exercise-induced plasma malondialdehyde (MDA) changes in CHF patients and to determine whether there is any association between plasma MDA levels and exercise capacity assessed by cardiopulmonary exercise testing. METHODS: Cardiopulmonary exercise testing was applied to 31 CHF patients (16 ischemic, 15 idiopathic) and controls. Rest and peak exercise blood samples were analyzed for MDA. RESULTS: Patients with CHF had elevation of plasma MDA levels during exercise compared with controls (p < 0.001 vs. p = 0.588). MDA change remained significant both in ischemic and idiopathic cardiomyopathy groups (p < 0.05 and p < 0.01, respectively). Delta MDA (peak exercise MDA - rest MDA) showed significant inverse correlation with peak oxygen consumption in patients with CHF. CONCLUSION: Lipid peroxidation is increased in patients with CHF during exercise regardless of etiology, and this increase is inversely related to oxygen consumption. |
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Authors:
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Nurten Sayar; Sait Terzi; Hale Yaka Yilmaz; Burak Tangurek; Tuba Bilsel; Nazmiye Cakmak; Lutfullah Orhan; Ayse Emre; Figen Ciloglu; Ismail Peker; Kemal Yesilcimen |
Publication Detail:
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Type: Journal Article Date: 2007-02-09 |
Journal Detail:
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Title: Cardiology Volume: 108 ISSN: 1421-9751 ISO Abbreviation: Cardiology Publication Date: 2007 |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2008-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 307-13 Citation Subset: IM |
Copyright Information:
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(c) 2007 S. Karger AG, Basel. |
Affiliation:
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Department of Cardiology, Siyami Ersek Cardiovascular Research and Training Hospital, Istanbul, Turkey. sayarnurten@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / blood Chronic Disease Exercise / physiology Exercise Test Exercise Tolerance / physiology* Female Heart Failure / blood, physiopathology* Humans Lipid Peroxidation / physiology* Male Malondialdehyde / blood Middle Aged Oxygen Consumption / physiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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