Document Detail

Exercise-induced hyperkalemia in hypothyroid dogs.
MedLine Citation:
PMID:  11900969     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of hypothyroidism in dogs on (1) the Na+-, K+ -ATPase concentration in skeletal muscle, and (2) potassium (K+) homeostasis at rest and during exercise. Prior to and 1 year after induction of hypothyroidism by surgery and subsequent radiothyroidectomy, the Na+-, K+ -ATPase concentrations were quantified in biopsies of sternothyroid muscles of seven Beagle dogs by measuring [3H]ouabain binding capacity. In addition, plasma K+ concentrations were measured at rest and after treadmill exercise in six hypothyroid and seven euthyroid Beagle dogs. During hypothyroidism, the mean Na+ -, K+ -ATPase concentration in muscle biopsies was 41% lower than during euthyroidism. The mean resting plasma K+ value of the hypothyroid dogs was significantly (14%) higher than that of the euthyroid dogs. In the hypothyroid dogs, plasma K+ concentration increased significantly during exercise, whereas there was no rise in the euthyroid dogs. The rise in plasma K+ concentration could not be ascribed to muscle damage, as plasma creatine kinase concentrations remained within reference range. Also renal K+ retention was an unlikely explanation, as plasma aldosterone concentration and plasma renin activity rather increased than decreased during exercise. In conclusion, hypothyroid dogs tend to develop hyperkalemia during exercise, which for a large part can be explained by the severe reduction of the Na+ -, K+ -ATPase capacity in the skeletal muscle pool.
I A Schaafsma; M G van Emst; H S Kooistra; C B Verkleij; M E Peeters; P Boer; A Rijnberk; M E Everts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Domestic animal endocrinology     Volume:  22     ISSN:  0739-7240     ISO Abbreviation:  Domest. Anim. Endocrinol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-19     Completed Date:  2002-05-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8505191     Medline TA:  Domest Anim Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-25     Citation Subset:  IM    
Department of Veterinary Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
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MeSH Terms
Aldosterone / blood
Creatine Kinase / blood
Dog Diseases / metabolism*
Hyperkalemia / etiology,  veterinary*
Hypothyroidism / complications,  metabolism,  veterinary*
Muscle, Skeletal / enzymology
Ouabain / metabolism
Physical Exertion*
Potassium / blood
Renin / blood
Sodium-Potassium-Exchanging ATPase / analysis
Reg. No./Substance:
10028-17-8/Tritium; 52-39-1/Aldosterone; 630-60-4/Ouabain; 7440-09-7/Potassium; EC Kinase; EC; EC ATPase

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