| Exercise induced hormonal and metabolic changes in Thoroughbred horses: effects of conditioning and acepromazine. | |
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MedLine Citation:
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PMID: 1884706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine Thoroughbred horses were assessed to determine the normal response of insulin, glucose, cortisol, plasma potassium (K) and erythrocyte K through conditioning and to exercise over 400 and 1,000 m. In addition, adrenaline, noradrenaline, cortisol, plasma K, erythrocyte K and L-lactate concentrations were evaluated in response to maximal exercise with and without the administration of acepromazine. Conditioning caused no obvious trends in plasma K, erythrocyte K, insulin or glucose concentration. Serum cortisol increased (P less than 0.05) from the initial sample at Week 1 to Weeks 4 and 5 (attributed to a response to training), and then decreased. During conditioning, three horses had low erythrocyte K concentrations (less than 89.3 mmol/litre). Further work is needed to define the significance of low erythrocyte K concentrations in the performance horse. In all tests maximal exercise increased plasma K, glucose and cortisol concentrations, whereas insulin and erythrocyte K concentrations decreased. Thirty minutes following exercise, plasma K and erythrocyte K concentrations returned to resting values; whereas glucose and cortisol concentrations continued to increase and the insulin concentration also was increased. The magnitude of the changes varied for pre-conditioned vs post-conditioned exercise tests and the duration of exercise. The administration of acepromazine prior to exercise over 1,000 m failed to alter the circulating noradrenaline and adrenaline concentrations in anticipation of exercise or 2 mins following exercise. Acepromazine administration, however, did cause lower L-lactate concentration 2 mins (P less than 0.03) and 30 mins (P less than or equal to 0.005) following exercise. Also, erythrocyte K showed a delayed return to baseline levels at 30 mins post exercise. Further evaluation of these trends may help explain the beneficial role acepromazine plays in limiting signs of exertional rhabdomyolysis when administered prior to exercise. |
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Authors:
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J F Freestone; K J Wolfsheimer; S G Kamerling; G Church; J Hamra; C Bagwell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Equine veterinary journal Volume: 23 ISSN: 0425-1644 ISO Abbreviation: Equine Vet. J. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-10-08 Completed Date: 1991-10-08 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 219-23 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge 70803-8422. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acepromazine
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pharmacology* Animals Blood Glucose / analysis Breeding Epinephrine / blood Exercise Test / veterinary Female Hormones / blood, secretion* Horses / metabolism* Hydrocortisone / blood Insulin / blood Lactates / blood Male Norepinephrine / blood Physical Conditioning, Animal* Potassium / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hormones; 0/Lactates; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 61-00-7/Acepromazine; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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