Document Detail

Exercise-induced hemostatic activation in patients with dilated cardiomyopathy in sinus rhythm.
MedLine Citation:
PMID:  18277136     Owner:  NLM     Status:  MEDLINE    
Abnormalities of baseline hemostatic variables have been related to a hypercoagulable state in patients with chronic heart failure (CHF). Given that physical exercise leads to an activation of coagulation physiologically, this study addressed the question of whether the exercise-induced hemostatic activation is enhanced in patients with CHF. Ten patients with dilated cardiomyopathy (ejection fraction < 40%) and 10 healthy individuals (matched for sex, age and body mass index) were subjected to a maximal exercise test on a bicycle ergometer. Healthy subjects performed a second exercise test at a submaximal intensity level, in which oxygen consumption (VO2) was adjusted to the peak oxygen consumption (VO2peak) of the corresponding patient. Exercise testing had only marginal effects on markers of thrombin formation in patients and healthy individuals alike. In patients with CHF, exercise-induced changes in fibrinopeptide A, an index of fibrin formation, paralleled those observed in controls after submaximal exercise whereas most pronounced changes occurred in healthy subjects after maximal exercise. Plasmin-antiplasmin complexes increased almost three-fold with maximal exercise in both groups, thus indicating a marked formation of plasmin. Maximal physical exercise does not induce an exaggerated formation of thrombin and fibrin in CHF patients. The fibrinolytic response to exercise in terms of plasmin formation is not compromised in patients with dilated cardiomyopathy.
Dirk Lossnitzer; Marco Amann; Christian Zugck; Hugo Katus; Peter Bärtsch; Claus Weiss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  19     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-15     Completed Date:  2008-05-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  146-52     Citation Subset:  IM    
University Hospital of Heidelberg, Department of Internal Medicine III (Cardiology), Heidelberg, Germany.
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MeSH Terms
Cardiomyopathy, Dilated / blood*
Case-Control Studies
Exercise / physiology*
Exercise Test
Exercise Tolerance
Fibrinolysin / metabolism*
Fibrinopeptide A / metabolism
Heart Failure / blood*
Middle Aged
Peptide Fragments
Protein Precursors
Thrombin / metabolism
Thrombophilia / blood*,  physiopathology
Reg. No./Substance:
0/Peptide Fragments; 0/Protein Precursors; 25422-31-5/Fibrinopeptide A; 72270-84-9/prothrombin fragment 1; 78768-79-3/prothrombin fragment 2; 9001-26-7/Prothrombin; EC; EC

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