| Exercise-induced hemolysis is caused by protein modification and most evident during the early phase of an ultraendurance race. | |
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MedLine Citation:
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PMID: 17284654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether structural changes of the erythrocyte membrane increase the susceptibility to hemolysis particularly of the relatively older cell population during the early phase of a 216-km ultrarace was tested in six male runners (age 53.6 +/- 10.4 yr, height 175.8 +/- 11.1 cm, body mass 75.9 +/- 8.4 kg). Erythrocyte membrane spectrins were lowest (P < 0.001) after 42 km (75.59 +/- 5.25% of prerace) and increased (P < 0.001) toward 216 km (88.27 +/- 3.37%). Susceptibility to osmotic hemolysis was highest (P < 0.01) after 42 km (107.34 +/- 3.02 mOsm sodium phosphate buffer) with almost identical (P > 0.05) values prerace (97.98 +/- 3.41 mOsm) and postrace (98.61 +/- 3.26 mOsm). Haptoglobin indicated intravascular hemolysis of 9.27 x 10(9) cells/l (P < 0.05) during the initial 84 km. Changes in hematocrit and plasma proteins indicated an estimated total net erythrocyte loss of 3.47 x 10(11) cells/l (P < 0.05) after 21 km. This was compensated by a gain in erythrocytes (P < 0.05) of 3.31 x 10(11) cells/l during the final 132 km. A main effect (P < 0.05) on erythropoietin suggests increased erythropoiesis throughout the race. Exercise-induced hemolysis reflects alterations in erythrocyte membrane spectrins and occurs particularly in the early phase of an ultraendurance race because of a relative older cell population. |
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Authors:
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Ashril Yusof; Renate M Leithauser; Heinz J Roth; Holger Finkernagel; Michael T Wilson; Ralph Beneke |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 102 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-07 Completed Date: 2007-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 582-6 Citation Subset: IM |
Affiliation:
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Centre for Sports and Exercise Science, Dept. of Biological Sciences, Univ. of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom. ashril@um.edu.my |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aging / physiology Erythrocyte Membrane / metabolism Erythropoiesis Erythropoietin / metabolism Exercise / physiology* Haptoglobins / metabolism Hemolysis / physiology* Humans Male Membrane Proteins / metabolism* Middle Aged Physical Endurance / physiology* Running / physiology Spectrin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Haptoglobins; 0/Membrane Proteins; 11096-26-7/Erythropoietin; 12634-43-4/Spectrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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