Document Detail


Exercise-induced expression of peroxisome proliferator-activated receptor γ coactivator-1α isoforms in skeletal muscle of endurance-trained males.
MedLine Citation:
PMID:  24907054     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of the present study was to investigate the effect of acute aerobic exercise on the expression of PGC-1α transcript variants in human skeletal muscle. Seven endurance-trained athletes performed a 90-min cycling test (62 % of [Formula: see text]o2max). At resting state, the levels of N-truncated (NT)-PGC-1α and PGC-1α exon 1a-derived transcripts were significantly higher (>20-fold; P < 0.05) than those of PGC-1α exon 1b- and 1c-derived transcripts. Acute exercise did not change the PGC-1α exon 1a-derived expression level, but it did increase the expression level of NT-PGC-1α mRNAs 6-fold, and the expression levels of PGC-1α exon 1b- and 1c-derived mRNAs >200-fold (P < 0.05). We conclude that NT-PGC-1α transcript expression in resting muscle and after acute moderate-intensity exercise constituted a significant share of total PGC-1α expression. The exercise led to a higher level of PGC-1α expression from alternative promoters (exon 1b- and 1c-derived mRNA) than from the canonical proximal promoter (exon 1a-derived mRNA).
Authors:
Daniil V Popov; Anton V Bachinin; Evgeny A Lysenko; Tatiana F Miller; Olga L Vinogradova
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-7
Journal Detail:
Title:  The journal of physiological sciences : JPS     Volume:  -     ISSN:  1880-6562     ISO Abbreviation:  J Physiol Sci     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262417     Medline TA:  J Physiol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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