Document Detail

Exercise-induced endocannabinoid signaling is modulated by intensity.
MedLine Citation:
PMID:  22990628     Owner:  NLM     Status:  MEDLINE    
Endocannabinoids (eCB) are endogenous ligands for cannabinoid receptors that are densely expressed in brain networks responsible for reward. Recent work shows that exercise activates the eCB system in humans and other mammals, suggesting eCBs are partly responsible for the reported improvements in mood and affect following aerobic exercise in humans. However, exercise-induced psychological changes reported by runners are known to be dependent on exercise intensity, suggesting that any underlying molecular mechanism should also change with varying levels of exercise intensity. Here, we examine circulating levels of eCBs following aerobic exercise (treadmill running) in recreationally fit human runners at four different intensities. We show that eCB signaling is indeed intensity dependent, with significant changes in circulating eCBs observed following moderate intensities only (very high and very low intensity exercises do not significantly alter circulating eCB levels). Our results are consistent with intensity-dependent psychological state changes with exercise and therefore support the hypothesis that eCB activity is related to neurobiological effects of exercise. Thus, future studies examining the role of exercise-induced eCB signaling on neurobiology or physiology must take exercise intensity into account.
David A Raichlen; Adam D Foster; Alexandre Seillier; Andrea Giuffrida; Gregory L Gerdeman
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-09-19
Journal Detail:
Title:  European journal of applied physiology     Volume:  113     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-05     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  869-75     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Arachidonic Acids / blood
Brain / metabolism*
Endocannabinoids / blood*
Exercise / physiology*,  psychology
Exercise Test
Muscle Contraction*
Muscle, Skeletal / metabolism*
Polyunsaturated Alkamides / blood
Signal Transduction*
Young Adult
Reg. No./Substance:
0/Arachidonic Acids; 0/Endocannabinoids; 0/Polyunsaturated Alkamides; 94421-68-8/anandamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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