Document Detail

Exercise-induced cholesterol depletion and Na+,K(+)-ATPase activities in human red cell membrane.
MedLine Citation:
PMID:  1336961     Owner:  NLM     Status:  MEDLINE    
Red cell membranes were isolated from blood samples obtained from athletes during exhaustive exercise on a bicycle ergometer and during the subsequent recovery period of 60 min. Plasma lactate levels were also determined. During exercise, cell membranes were progressively depleted of cholesterol and, at exhaustion, membrane cholesterol was less than 80% of the initial level. A parallel decline in Na+,K(+)-ATPase was also noted, while phospholipid reduction was around 5%. During recovery, the erythrocyte membrane cholesterol and Na+,K(+)-ATPase increased, but at a slow rate and were inversely proportional to plasma lactate content.
K R Shanmugasundaram; C Padmavathi; S Acharya; N Vidhyalakshmi; V K Vijayan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental physiology     Volume:  77     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-26     Completed Date:  1993-02-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  933-6     Citation Subset:  IM    
Department of Biochemistry, University of Madras, India.
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MeSH Terms
Cholesterol / blood,  deficiency*
Erythrocyte Membrane / metabolism*
Exercise Test
Lactates / blood
Lactic Acid
Phospholipids / blood
Physical Exertion*
Sodium-Potassium-Exchanging ATPase / blood*
Reg. No./Substance:
0/Lactates; 0/Phospholipids; 50-21-5/Lactic Acid; 57-88-5/Cholesterol; EC ATPase
Erratum In:
Exp Physiol 1993 Jul;78(4):553

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