Document Detail

Exercise-induced changes in left ventricular function after phlebotomy in patients with polycythemic COPD.
MedLine Citation:
PMID:  2362307     Owner:  NLM     Status:  MEDLINE    
The exercise capacity of polycythemic COPD patients has been shown to improve after phlebotomy, possibly because of reduction of ventricular afterload by decreased blood viscosity, resulting in increased cardiac output. Ten patients with polycythemic COPD and mean hematocrit 62% were studied at rest and during exercise before and after reduction of mean hematocrit to 50% by repeated phlebotomy. Pulmonary function was evaluated by physiologic exercise testing on a bicycle ergometer. Cardiac function was evaluated by rest and exercise RNVG. Significant increase in exercise tolerance and maximal oxygen uptake at peak exercise, with significant reduction in mean systemic BP, were demonstrated. Ejection fractions did not change, but dV/dt for ejection from the left ventricle at peak exercise improved significantly. Mean SV counts, ESV counts, and EDV counts were measured and the fractional increase with exercise compared for prephlebotomy and postphlebotomy, assuming that resting volumes would not change. ESV counts and EDV counts were both proportionately, though not significantly, reduced postphlebotomy. The data tend to support the hypothesis that the afterload on the left ventricle is reduced, with resulting improved myocardial contractility and left ventricular function. Improved peripheral oxygen uptake may also be a factor.
N Milne; R W Light; K G Chetty
Related Documents :
2985387 - Radionuclide determination of right and left ventricular stroke volumes.
14600927 - The comparison of two gated spet protocols: adenosine tc-99m tetrofosmin and treadmill ...
6849267 - Determinants of variable exercise performance among patients with severe left ventricul...
1396857 - Right ventricular performance in arterial hypertension.
3876407 - Entry of methotrexate into streptococcus pneumoniae: a study on a wild-type strain and ...
3171787 - Role of conventional physiotherapy in cystic fibrosis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of thoracic imaging     Volume:  5     ISSN:  0883-5993     ISO Abbreviation:  J Thorac Imaging     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-08     Completed Date:  1990-08-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8606160     Medline TA:  J Thorac Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  IM    
Nuclear Medicine Service, Veterans Affairs Medical Center, Long Beach, California 90822.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiac Output / physiology*
Exercise Test*
Heart / physiopathology*
Heart Ventricles
Lung Diseases, Obstructive / physiopathology*,  surgery
Middle Aged
Polycythemia / physiopathology*,  surgery
Regression Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Retrograde jejuno-jejunal intussusception. A rare complication following total gastric resection
Next Document:  Bacterial aetiology of infantile diarrhoea in Papua New Guinea.