Document Detail

Exercise-induced cardioprotection is mediated by a bloodborne, transferable factor.
MedLine Citation:
PMID:  22426795     Owner:  NLM     Status:  MEDLINE    
Exercise protects against myocardial ischemia-reperfusion (I-R) injury but the mechanism remains unclear. Protection can be transferred from a remotely preconditioned human donor to an isolated perfused rabbit heart using a dialysate of plasma. We hypothesized that physical exercise preconditioning also confers cardioprotection through a humorally mediated effector dependent on opioid receptor activation. Thirteen male volunteers performed vigorous exercise (four 2-minute bouts of high-intensity exercise) and 1 week later they underwent remote ischemic preconditioning (four cycles of 5 min upper limb ischemia and reperfusion). Dialysates were prepared from blood collected before (control) and after the two interventions. Isolated rabbit hearts were perfused with the dialysates without and with co-administration of naloxone (opioid receptor antagonist) prior to 40 min regional ischemia and 2 h reperfusion. Exercise and remote ischemic preconditioning (rIPC) reduced infarct size from 60 ± 5 to 35 ± 5 % and from 57 ± 7 to 27 ± 3 % of the area at risk, respectively (p < 0.05 and < 0.01). Furthermore, post-ischemic left ventricular developed pressure was improved compared with controls (p = 0.08 for exercise and p = 0.04 for rIPC). Co-perfusion with naloxone abrogated the protective effects of exercise and remote ischemic preconditioned dialysates. In conclusion, high-intensity exercise preconditioning elicits cardioprotection through a humorally mediated dependent on opioid receptor activation, similar to rIPC.
M M Michelsen; N B Støttrup; M R Schmidt; B Løfgren; R V Jensen; M Tropak; E Jean St-Michel; A N Redington; H E Bøtker
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-18
Journal Detail:
Title:  Basic research in cardiology     Volume:  107     ISSN:  1435-1803     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-03-19     Completed Date:  2012-07-09     Revised Date:  2014-08-20    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  260     Citation Subset:  IM    
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MeSH Terms
Blood Transfusion*
Ischemic Preconditioning / methods*
Lactic Acid / metabolism
Myocardial Infarction / blood,  pathology,  physiopathology,  prevention & control*
Myocardial Reperfusion Injury / blood,  pathology,  physiopathology,  prevention & control*
Myocardium / metabolism,  pathology
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Paracrine Communication* / drug effects
Time Factors
Upper Extremity / blood supply*
Ventricular Function, Left
Ventricular Pressure
Young Adult
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Narcotic Antagonists; 33X04XA5AT/Lactic Acid; 36B82AMQ7N/Naloxone

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