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Exercise-induced bronchoconstriction in school-age children born extremely preterm.
MedLine Citation:
PMID:  23269119     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background.School children born preterm often show airway hyperresponsiveness to methacholine or histamine. Less attention has been paid to their airway response to exercise, an important point because of the role of exercise in the child's daily life. The aim of this study was to describe the characteristics of, and potential determinants to, the airway response to exercise in children born extremely preterm.Methods.Forty-two nonasthmatic non atopic children born before 32 weeks gestation were compared to 27 healthy nonasthmatic non atopic term children at age 7. Spirometry and respiratory impedance were measured at baseline and repeated after a single-step six-minute treadmill exercise in a climate-controlled room.Results.The preterm group showed significant bronchoconstriction induced by exercise. Prematurity, but not low baseline lung function, neonatal oxygen supplementation, mechanical ventilation, chronic lung disease or maternal smoking, was a determinant of exercise-induced bronchoconstriction.Conclusion.Children born extremely preterm present significant exercise-induced airway obstruction at age 7. The response has different characteristics from that occurring in asthmatics, and is likely to express airway noneosinophilic inflammation.Pediatric Research (2012); doi:10.1038/pr.2012.202.
Authors:
Isabelle Hamon; Silvia Varechova; Rachel Vieux; Iulia Ioan; Claude Bonabel; Cyril Schweitzer; Jean Michel Hascoet; François Marchal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-26
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Department of Neonatal Medicine, Regional Maternity Hospital, Nancy, France [2] Department of Physiology, Faculty of Medicine, Lorraine University, Nancy, France.
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