Document Detail

Exercise-induced bronchoconstriction: elucidating the roles of leukotrienes and prostaglandins.
MedLine Citation:
PMID:  9017786     Owner:  NLM     Status:  MEDLINE    
Exercise-induced bronchoconstriction (EIB) is prevalent among patients with symptomatic asthma, especially those with moderate-to-severe airway hyperresponsiveness. This phenomenon generally manifests within the first 3-5 minutes after exercise, during which the forced expiratory volume in 1 second (FEV1) markedly decreases. Usually, the FEV1 gradually returns to baseline within an hour. Exercise should not be avoided in patients with asthma, since improved physical fitness can reduce the minute ventilation associated with a given exercise work rate and, thereby, reduce the bronchoconstrictive response. The cysteinyl leukotrienes are becoming recognized as important mediators in EIB, and prostaglandins (released at least partially as a result of leukotriene stimulation) are gaining recognition for their protective effects. Thus, pharmacologic agents that either reduce leukotriene activity or enhance prostaglandin activity, or agents that do both, may enhance prophylaxis against EIB. Currently, beta-agonists and cromolyn sodium are the mainstays of prophylactic therapy for EIB.
P M O'Byrne
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  17     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:    1997 Jan-Feb
Date Detail:
Created Date:  1997-04-08     Completed Date:  1997-04-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31S-38S     Citation Subset:  IM    
Department of Medicine, McMaster University Health Science Center, Hamilton, Ontario, Canada.
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MeSH Terms
Asthma, Exercise-Induced / physiopathology*,  prevention & control
Bronchoconstriction / drug effects,  physiology*
Leukotrienes / physiology
Reg. No./Substance:

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