Document Detail


Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry.
MedLine Citation:
PMID:  16840654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exhaled nitric oxide (NO) is altered in asthmatic subjects with exercise-induced bronchoconstriction (EIB). However, the physiological interpretation of exhaled NO is limited because of its dependence on exhalation flow and the inability to distinguish completely proximal (large airway) from peripheral (small airway and alveolar) contributions. We estimated flow-independent NO exchange parameters that partition exhaled NO into proximal and peripheral contributions at baseline, postexercise challenge, and postbronchodilator administration in steroid-naive mild-intermittent asthmatic subjects with EIB (24-43 yr old, n = 9) and healthy controls (20-31 yr old, n = 9). The mean +/- SD maximum airway wall flux and airway diffusing capacity were elevated and forced expiratory flow, midexpiratory phase (FEF(25-75)), forced expiratory volume in 1 s (FEV(1)), and FEV(1)/forced vital capacity (FVC) were reduced at baseline in subjects with EIB compared with healthy controls, whereas the steady-state alveolar concentration of NO and FVC were not different. Compared with the response of healthy controls, exercise challenge significantly reduced FEV(1) (-23 +/- 15%), FEF(25-75) (-37 +/- 18%), FVC (-12 +/- 12%), FEV(1)/FVC (-13 +/- 8%), and maximum airway wall flux (-35 +/- 11%) relative to baseline in subjects with EIB, whereas bronchodilator administration only increased FEV(1) (+20 +/- 21%), FEF(25-75) (+56 +/- 41%), and FEV(1)/FVC (+13 +/- 9%). We conclude that mild-intermittent steroid-naive asthmatic subjects with EIB have altered airway NO exchange dynamics at baseline and after exercise challenge but that these changes occur by distinct mechanisms and are not correlated with alterations in spirometry.
Authors:
Hye-Won Shin; Christina D Schwindt; Anna S Aledia; Christine M Rose-Gottron; Jennifer K Larson; Robert L Newcomb; Dan M Cooper; Steven C George
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-07-13
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  291     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2006-12-26     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1741-8     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Division of Pulmonary and Critical Care, 3120 Natural Sciences II, University of California-Irvine, Irvine, CA 92697-2715, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adult
Asthma, Exercise-Induced / physiopathology*
Bronchoconstriction*
Exercise
Exercise Test
Female
Humans
Lung / physiopathology*
Male
Nitric Oxide / metabolism*
Pulmonary Gas Exchange*
Spirometry / methods*
Grant Support
ID/Acronym/Agency:
ES 014923/ES/NIEHS NIH HHS; HD 23969/HD/NICHD NIH HHS; HL 070645/HL/NHLBI NIH HHS; RR 00827/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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