Document Detail


Exercise-induced asthma may be associated with diminished sweat secretion rates in humans.
MedLine Citation:
PMID:  18641089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Muscarinic receptor agonists increase water secretion from the acinar cells of respiratory, sweat, salivary, and lacrimal glands. Mice lacking the gene for aqueous water channel aquaporin (Aqp) 5 exhibit methacholine-induced bronchiolar hyperreactivity when compared to normal mice. Individuals with asthma also have enhanced airway responsiveness to methacholine and diminished airway hydration. Because Aqp5 in humans is also expressed in respiratory, sweat, salivary, and lacrimal glands, we hypothesized that those individuals with exercise-induced asthma and excessive bronchiolar reactivity should also have decreased muscarinic receptor-dependent sweat, salivary, and tear gland secretions. METHODS: Healthy, athletic subjects who are suspected of having exercise-induced bronchospasm were recruited, and FEV(1) values were determined following provocative airway challenges with methacholine. Measurements of pilocarpine-induced sweat secretion were taken in 56 volunteers, and some additional subjects also had timed collections of saliva and tear production. RESULTS: Subjects manifesting excessive airway reactivity demonstrated by exaggerated methacholine-induced reductions in FEV(1) also had diminished values for pilocarpine-induced sweat secretion (n = 56; r = - 0.59; p < 0.0001). The rate of pilocarpine-stimulated sweat secretion in our subjects correlated highly with salivary flow rate (r = 0.69; p < 0.0001) and tearing rate (r = 0.86; p < 0.001). CONCLUSION: Hyperhidrosis, sialorrhea, and excessive tearing are traits that may indicate a phenotype that predicts resistance to hyperactive airway diseases such as exercise-induced asthma in humans.
Authors:
Chan Park; Christopher Stafford; Warren Lockette
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Publication Detail:
Type:  Journal Article     Date:  2008-07-18
Journal Detail:
Title:  Chest     Volume:  134     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2008-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  552-8     Citation Subset:  AIM; IM    
Affiliation:
Clinical Investigations Department, Naval Medical Center-San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asthma, Exercise-Induced / physiopathology*,  prevention & control*
Bronchial Provocation Tests
Cohort Studies
Female
Forced Expiratory Volume / drug effects,  physiology
Humans
Male
Methacholine Chloride / pharmacology
Muscarinic Agonists / pharmacology
Pilocarpine / pharmacology
Receptors, Muscarinic / drug effects,  physiology
Saliva / drug effects,  physiology
Sweating / drug effects,  physiology*
Tears / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Muscarinic Agonists; 0/Receptors, Muscarinic; 62-51-1/Methacholine Chloride; 92-13-7/Pilocarpine

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