Document Detail


Exercise-induced asthma: critical analysis of the protective role of montelukast.
MedLine Citation:
PMID:  21437147     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Exercise-induced asthma/exercise-induced bronchospasm (EIA/EIB) is a prevalent and clinically important disease affecting young children through older adulthood. These terms are often used interchangeably and the differences are not clearly defined in the literature. The pathogenesis of EIA/EIB may be different in those with persistent asthma compared to those with exercise-induced symptoms only. The natural history of EIA is unclear and may be different for elite athletes. Leukotriene biology has helped the understanding of EIB. The type and intensity of exercise are important factors for EIB. Exercise participation is necessary for proper development and control of EIA is recommended. Symptoms of EIB should be confirmed by proper testing. Biologic markers may also be helpful in diagnosis. Not all exercise symptoms are from EIB. Many medication and nonpharmacologic treatments are available. Asthma education is an important component of managing EIA. Many medications have been tested and the comparisons are complicated. Montelukast is a US Food and Drug Administration-approved asthma and EIB controller and has a number of potential advantages to other asthma medications including short onset of action, ease of use, and lack of tolerance. Not all patients improve with montelukast and rescue medication should be available.
Authors:
Terrence W Carver
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Publication Detail:
Type:  Journal Article     Date:  2009-10-22
Journal Detail:
Title:  Journal of asthma and allergy     Volume:  2     ISSN:  1178-6965     ISO Abbreviation:  J Asthma Allergy     Publication Date:  2009  
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101543450     Medline TA:  J Asthma Allergy     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  93-103     Citation Subset:  -    
Affiliation:
The Children's Mercy Hospital and Clinics, Kansas City, MO, USA.
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