Document Detail

Exercise-induced asthma and cardiovascular fitness in asthmatic children.
MedLine Citation:
PMID:  8711660     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The role of physical training in the management of children with exercise-induced asthma is controversial. A study was undertaken to determine whether a relationship could be found between the occurrence of exercise-induced asthma and the degree of cardiovascular fitness in asthmatic children. METHODS: Twenty eight children aged 6-13 with mild to moderate asthma and dyspnoea during or after physical exercise were tested. All patients had a basal forced expiratory volume in one second (FEV1) of > 80% predicted. Twelve patients were taking corticosteroid maintenance medication by inhalation and 16 were not. Two exercise tests were performed on a treadmill to assess peak oxygen consumption rate (VO2max) and the percentage decrease in FEV1 after exercise. RESULTS: There was no correlation between the VO2max and the percentage decrease in FEV1. Patients not taking steroids showed a greater fall in FEV1 than those receiving corticosteroid medication (mean fall in FEV1 28.7% versus 6.6%). Four of the 12 children treated with steroids and two of the 16 children not taking steroids had a level of cardiovascular fitness lower than the 5th percentile for healthy Dutch children. CONCLUSION: Normal cardiovascular fitness does not prevent exercise-induced asthma.
B J Thio; A F Nagelkerke; A G Ketel; B L van Keeken; J E Dankert-Roelse
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thorax     Volume:  51     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-09-12     Completed Date:  1996-09-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  207-9     Citation Subset:  IM    
Department of Paediatric Pulmonogy, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, Netherlands.
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MeSH Terms
Albuterol / therapeutic use
Asthma, Exercise-Induced / drug therapy,  physiopathology*
Bronchodilator Agents / therapeutic use
Cardiovascular Physiological Phenomena*
Exercise Test
Forced Expiratory Volume
Oxygen Consumption
Physical Fitness*
Reg. No./Substance:
0/Bronchodilator Agents; 18559-94-9/Albuterol

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