Document Detail

Exercise-induced alterations in pro-inflammatory cytokines and prostaglandin F2alpha in horses.
MedLine Citation:
PMID:  17617470     Owner:  NLM     Status:  MEDLINE    
Using an established standardized exercise test on a high-speed treadmill, thirteen Thoroughbred racehorses were exercised to fatigue (failure); blood samples were obtained before exercise, at failure, and at 2, 6, 24, 48, and 72 h after exercise. The exercise test induced a systemic inflammatory response characterized by a mild transient endotoxemia, leukocytosis, increased leukocyte expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, and IL-6, and increased circulating concentrations of TNF-alpha and prostaglandin F2 alpha (PGF 2 alpha), with the most pronounced changes being evident at failure and 2h after exercise. Expression of mRNA for IL-6, TNF-alpha, and IL-1 beta was increased by 120-fold, three-fold, and four-fold, respectively, when compared to pre-exercise values. Plasma concentrations of 6-keto-PGF1alpha and PGE2 did not change in response to the exercise test. Collectively, these findings indicate that brief, strenuous exercise induces endotoxemia and a systemic pro-inflammatory response in horses that persists for at least 2h.
Douglas C Donovan; Christie A Jackson; Patrick T Colahan; Natalie Norton; David J Hurley
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-03
Journal Detail:
Title:  Veterinary immunology and immunopathology     Volume:  118     ISSN:  0165-2427     ISO Abbreviation:  Vet. Immunol. Immunopathol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002006     Medline TA:  Vet Immunol Immunopathol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30605, USA.
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MeSH Terms
Acid-Base Equilibrium
Cytokines / blood,  metabolism*
Dinoprost / blood*
Endotoxins / blood
Gene Expression
Horses / blood*,  physiology*
Interleukin-1beta / genetics,  metabolism
Interleukin-6 / genetics,  metabolism
Leukocytes / metabolism
Physical Conditioning, Animal / physiology*
Tumor Necrosis Factor-alpha / blood,  genetics
Reg. No./Substance:
0/Cytokines; 0/Endotoxins; 0/Interleukin-1beta; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 551-11-1/Dinoprost

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