| Exercise-induced alterations in pro-inflammatory cytokines and prostaglandin F2alpha in horses. | |
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MedLine Citation:
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PMID: 17617470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using an established standardized exercise test on a high-speed treadmill, thirteen Thoroughbred racehorses were exercised to fatigue (failure); blood samples were obtained before exercise, at failure, and at 2, 6, 24, 48, and 72 h after exercise. The exercise test induced a systemic inflammatory response characterized by a mild transient endotoxemia, leukocytosis, increased leukocyte expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, and IL-6, and increased circulating concentrations of TNF-alpha and prostaglandin F2 alpha (PGF 2 alpha), with the most pronounced changes being evident at failure and 2h after exercise. Expression of mRNA for IL-6, TNF-alpha, and IL-1 beta was increased by 120-fold, three-fold, and four-fold, respectively, when compared to pre-exercise values. Plasma concentrations of 6-keto-PGF1alpha and PGE2 did not change in response to the exercise test. Collectively, these findings indicate that brief, strenuous exercise induces endotoxemia and a systemic pro-inflammatory response in horses that persists for at least 2h. |
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Authors:
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Douglas C Donovan; Christie A Jackson; Patrick T Colahan; Natalie Norton; David J Hurley |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-03 |
Journal Detail:
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Title: Veterinary immunology and immunopathology Volume: 118 ISSN: 0165-2427 ISO Abbreviation: Vet. Immunol. Immunopathol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002006 Medline TA: Vet Immunol Immunopathol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 263-9 Citation Subset: IM |
Affiliation:
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Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30605, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium Animals Cytokines / blood, metabolism* Dinoprost / blood* Endotoxins / blood Gene Expression Horses / blood*, physiology* Interleukin-1beta / genetics, metabolism Interleukin-6 / genetics, metabolism Leukocytes / metabolism Male Physical Conditioning, Animal / physiology* Tumor Necrosis Factor-alpha / blood, genetics |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Endotoxins; 0/Interleukin-1beta; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 551-11-1/Dinoprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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