Document Detail

Exercise-induced alterations in natural killer cell number and function.
MedLine Citation:
PMID:  8897029     Owner:  NLM     Status:  MEDLINE    
To study the effects of exercise on natural killer (NK) cell number and activity (NKCA) healthy male (n = 32) and female (n = 32) subjects were randomly assigned to an exercise or control condition. Exercise involved a continuous incremental protocol consisting of cycling for three periods of 6 min at work rates corresponding to 55%, 70% and 85% peak oxygen uptake (VO2peak). Blood samples were drawn at baseline, at 6 min, 12 min and 18 min during exercise, and at 2 h following completion of exercise. Relative to both baseline and control conditions, exercise resulted in an increase in the number of circulating lymphocytes. The proportion of T cells (CD3+) and B cells (CD19+) significantly decreased, and NK cells (CD3-CD16+CD56+) increased throughout exercise. NKCA increased (P < 0.001) during the initial 6 min of exercise with no further changes observed, despite increases (P < 0.001) in the number and proportion of circulating NK cells during exercise at 70% and 85% VO2peak. Plasma epinephrine and norepinephrine increased (P < 0.001) above baseline at 12 min and 18 min. The changes in NK cell number and function were independent of gender. The results indicate that short-duration low-intensity exercise can significantly increase NK cell number and activity. However, alterations in NK cell number are not accompanied by changes of a similar magnitude in NKCA.
N M Moyna; G R Acker; K M Weber; J R Fulton; R J Robertson; F L Goss; B S Rabin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  74     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-04     Completed Date:  1997-02-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
Department of Pathology, University of Pittsburgh Medical Center, PA 15213-2582, USA.
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MeSH Terms
B-Lymphocytes / physiology
Epinephrine / blood
Killer Cells, Natural / physiology*
Lymphocyte Count*
Norepinephrine / blood
Physical Exertion* / physiology
T-Lymphocytes / physiology
Grant Support
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

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