| Exercise-induced alterations in natural killer cell number and function. | |
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MedLine Citation:
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PMID: 8897029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the effects of exercise on natural killer (NK) cell number and activity (NKCA) healthy male (n = 32) and female (n = 32) subjects were randomly assigned to an exercise or control condition. Exercise involved a continuous incremental protocol consisting of cycling for three periods of 6 min at work rates corresponding to 55%, 70% and 85% peak oxygen uptake (VO2peak). Blood samples were drawn at baseline, at 6 min, 12 min and 18 min during exercise, and at 2 h following completion of exercise. Relative to both baseline and control conditions, exercise resulted in an increase in the number of circulating lymphocytes. The proportion of T cells (CD3+) and B cells (CD19+) significantly decreased, and NK cells (CD3-CD16+CD56+) increased throughout exercise. NKCA increased (P < 0.001) during the initial 6 min of exercise with no further changes observed, despite increases (P < 0.001) in the number and proportion of circulating NK cells during exercise at 70% and 85% VO2peak. Plasma epinephrine and norepinephrine increased (P < 0.001) above baseline at 12 min and 18 min. The changes in NK cell number and function were independent of gender. The results indicate that short-duration low-intensity exercise can significantly increase NK cell number and activity. However, alterations in NK cell number are not accompanied by changes of a similar magnitude in NKCA. |
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Authors:
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N M Moyna; G R Acker; K M Weber; J R Fulton; R J Robertson; F L Goss; B S Rabin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of applied physiology and occupational physiology Volume: 74 ISSN: 0301-5548 ISO Abbreviation: Eur J Appl Physiol Occup Physiol Publication Date: 1996 |
Date Detail:
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Created Date: 1997-02-04 Completed Date: 1997-02-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0410266 Medline TA: Eur J Appl Physiol Occup Physiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 227-33 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Pittsburgh Medical Center, PA 15213-2582, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult B-Lymphocytes / physiology Epinephrine / blood Female Humans Killer Cells, Natural / physiology* Lymphocyte Count* Male Norepinephrine / blood Physical Exertion* / physiology T-Lymphocytes / physiology |
| Grant Support | |
ID/Acronym/Agency:
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MH43411/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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