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Exercise-induced Growth Hormone Secretion in the Assessment of Growth Hormone Deficiency in Adult Individuals.
MedLine Citation:
PMID:  21856788     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective The role of exercise testing in the assessment of growth hormone deficiency (GHD) in adult patients is currently unclear. This study aimed at evaluating the diagnostic value of exercise-induced GH levels in the detection of severe GHD in adult patients. Methods Fourteen patients confirmed to have severe GHD according to current guidelines and 20 healthy control individuals (CI) exercised for 120minutes at 50-60% of their individual VO2max. GH was measured before and every 30 minutes throughout exercise. The diagnostic value of predicting GHD was assessed by performing receiver operating characteristics (ROC) analysis for each time point of GH-assessment. To optimise comparability within the study population a sub-analysis with 10 individuals specifically matched for gender, age, BMI, and waist was performed. Results Exercise-induced GH secretion was significantly lower in patients with GHD than in CI (p<0.001). Area under the ROC curve (AUCROC) was 0.954±0.033, 0.993±0.009, 0.989±0.012 and 0.992±0.009 for the overall population and 0.870±0.086, 0.980±0.024, 0.970±0.034 and 0.978±0.027 for the matched individuals at 30, 60, 90, and 120 minutes of exercise, respectively. At 60 minutes of exercise a cut-off GH value of 2.4ng/ml translates into a sensitivity of 100% and a specificity of 95% and 90% in the diagnosis of GHD for the overall population and matched individuals, respectively. Conclusion GH assessment during a standardized aerobic exercise of moderate intensity is a reliable test with high diagnostic accuracy in predicting severe GHD in adult individuals. Based on the current findings an exercise duration of 60 minutes appears to be sufficient for diagnostic purposes.
Authors:
Thomas Zueger; Sabin Allemann; Emanuel R Christ; Christoph Stettler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-19
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
T Zueger, Division of Endocrinology, Diabetes and Clinical Nutrition, Bern University Hospital and University of Bern, Bern, Switzerland.
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