Document Detail

Exercise increases soluble adhesion molecules ICAM-1 and VCAM-1 in patients with intermittent claudication.
MedLine Citation:
PMID:  11455059     Owner:  NLM     Status:  MEDLINE    
Adhesion molecules play a relevant role in the pathogenesis of vascular diseases. In 21 patients with intermittent claudication and 18 sex- and age-matched control subjects, we measured plasma levels of the circulating form of the adhesion molecules E-selectin, P-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) alongside von Willebrand factor (vWF), at rest, at maximally tolerated exercise and 5, 15 and 30 min after exercise. In controls, plasma sICAM-1 levels did not change with exercise, while in claudicants they increased from 285+/-15 to 317+/-16 ng/ml (p<0.01). Also for sVCAM-1 exercise did not modify plasma levels of sVCAM-1 in controls but increased it in claudicants from 671+/-45 to 751+/-47 ng/ml (p<0.05). Similarly, vWF did not change with exercise in controls, but increased in claudicants from 100+/-9% to 111+/-8% of value for pooled normal plasma (p<0.05). Exercise-induced changes in sICAM-1 negatively correlated with the maximal tolerated walking time, which is an index of disease severity. These findings indicate that, in claudicants, exercise is associated with increase in plasma levels of sICAM-1 and sVCAM-1.
G Brevetti; M De Caterina; V D Martone; B Ungaro; F Corrado; A Silvestro; T de Cristofaro; F Scopacasa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  24     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2001  
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-10-11     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  193-9     Citation Subset:  IM    
Department of Medicine, University FedericoII, Naples, Italy.
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MeSH Terms
Analysis of Variance
Blood Pressure
Brachial Artery / physiology,  physiopathology
E-Selectin / blood
Exercise Test*
Intercellular Adhesion Molecule-1 / blood*
Intermittent Claudication / blood*,  physiopathology
Middle Aged
P-Selectin / blood
Physical Exertion / physiology*
Reference Values
Time Factors
Vascular Cell Adhesion Molecule-1 / blood*
von Willebrand Factor / metabolism
Reg. No./Substance:
0/E-Selectin; 0/P-Selectin; 0/Vascular Cell Adhesion Molecule-1; 0/von Willebrand Factor; 126547-89-5/Intercellular Adhesion Molecule-1

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