| Exercise increases soluble adhesion molecules ICAM-1 and VCAM-1 in patients with intermittent claudication. | |
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MedLine Citation:
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PMID: 11455059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adhesion molecules play a relevant role in the pathogenesis of vascular diseases. In 21 patients with intermittent claudication and 18 sex- and age-matched control subjects, we measured plasma levels of the circulating form of the adhesion molecules E-selectin, P-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) alongside von Willebrand factor (vWF), at rest, at maximally tolerated exercise and 5, 15 and 30 min after exercise. In controls, plasma sICAM-1 levels did not change with exercise, while in claudicants they increased from 285+/-15 to 317+/-16 ng/ml (p<0.01). Also for sVCAM-1 exercise did not modify plasma levels of sVCAM-1 in controls but increased it in claudicants from 671+/-45 to 751+/-47 ng/ml (p<0.05). Similarly, vWF did not change with exercise in controls, but increased in claudicants from 100+/-9% to 111+/-8% of value for pooled normal plasma (p<0.05). Exercise-induced changes in sICAM-1 negatively correlated with the maximal tolerated walking time, which is an index of disease severity. These findings indicate that, in claudicants, exercise is associated with increase in plasma levels of sICAM-1 and sVCAM-1. |
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Authors:
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G Brevetti; M De Caterina; V D Martone; B Ungaro; F Corrado; A Silvestro; T de Cristofaro; F Scopacasa |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical hemorheology and microcirculation Volume: 24 ISSN: 1386-0291 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-07-16 Completed Date: 2001-10-11 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
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Languages: eng Pagination: 193-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, University FedericoII, Naples, Italy. brevetti@unina.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Blood Pressure Brachial Artery / physiology, physiopathology E-Selectin / blood Exercise Test* Female Humans Intercellular Adhesion Molecule-1 / blood* Intermittent Claudication / blood*, physiopathology Male Middle Aged P-Selectin / blood Physical Exertion / physiology* Reference Values Smoking Time Factors Vascular Cell Adhesion Molecule-1 / blood* von Willebrand Factor / metabolism |
| Chemical | |
Reg. No./Substance:
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0/E-Selectin; 0/P-Selectin; 0/Vascular Cell Adhesion Molecule-1; 0/von Willebrand Factor; 126547-89-5/Intercellular Adhesion Molecule-1 |
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