Document Detail


Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes.
MedLine Citation:
PMID:  22340256     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of the study was to determine the effect of a single bout of exercise on GLUT4 gene expression in muscle of patients with type 2 diabetes (T2D) and control subjects, matched for age and body mass index (BMI). Nine patients with T2D and nine control subjects performed 60 min of cycling exercise at 55% peak power (W(max) ). Skeletal muscle biopsies were obtained at baseline, immediately post and 3 h post exercise. GLUT4 mRNA expression increased (p<0.05) to a similar extent immediately post exercise in control (60%) and T2D (66%) subjects, and remained elevated (p<0.05) 3 hrs post exercise with no differences between groups. Similarly, p-AMPK, p-38 MAPK and PGC-1α mRNA expression were increased (p<0.05) post exercise, and were not different between the groups. In conclusion, a single bout of exercise increased skeletal muscle GLUT4 mRNA expression in patients with T2D to a similar extent as in control subjects.
Authors:
Se Hussey; Sl McGee; A Garnham; Gk McConell; M Hargreaves
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-16
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  -     ISSN:  1463-1326     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Physiology, The University of Melbourne, VIC 3010, Australia School of Medicine, Deakin University, VIC 3217, Australia School of Exercise and Nutrition Sciences, Deakin University, VIC 3125, Australia Institute of Sport, Exercise and Active Living (ISEAL) and the School of Biomedical and Health Sciences, Victoria University, VIC 8001, Australia.
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