| Exercise increases plasma levels of sphingoid base-1 phosphates in humans. | |
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MedLine Citation:
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PMID: 21535416 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: In recent years blood sphingolipids attracted much attention and have been implicated in both pathophysiology and prevention of cardiovascular diseases and insulin resistance. However, factors affecting concentration and metabolism of sphingolipids in blood remain poorly recognized. We have previously found that exercise alters skeletal muscle sphingolipid metabolism. This finding prompted us to examine whether physical activity induces similar effects in blood. Methods: Twenty healthy male subjects were assigned to either untrained (UT, n=10) or endurance trained (ET, n=10) group. The subjects performed either a 30 (UT group) or 60 (ET group) minute exercise on a cycloergometer at a workload corresponding to 70% of VO(2 max) . Blood samples were taken just before exercise, after 30 and 60 (ET group only) minutes of pedaling, and following a 30 minute rest. Results: ET subjects were characterized by higher basal plasma sphingosine-1-phosphate (S1P) concentration and decreased content of sphingosine, S1P, sphinganine-1-phosphate (SA1P) and ceramide in erythrocytes. In ET group plasma concentrations of all measured sphingolipids remained stable both during and after exercise. On the other hand, in UT subjects the post-exercise levels of S1P and SA1P were markedly higher compared to the baseline values and this effect was accompanied by decreased erythrocyte ceramide content. Conclusion: It is likely that single bout of exercise and endurance training enhance production and release of sphingoid base-1 phosphates by erythrocytes. We speculate that exercise-induced increase in plasma S1P concentration might be one of the mechanisms underlying beneficial effects of physical activity on cardiovascular health and insulin sensitivity. |
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Authors:
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Marcin Baranowski; Małgorzata Charmas; Barbara Długołęcka; Jan Górski |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-2 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: - ISSN: 1748-1716 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Scandinavian Physiological Society. |
Affiliation:
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Department of Physiology, Medical University of Białystok, Białystok, Poland Department of Biochemistry, Faculty of Physical Education and Sport, Józef Piłsudski University of Physical Education, Biała Podlaska, Poland. |
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