Document Detail

Exercise increases inflammatory macrophage antitumor cytotoxicity.
MedLine Citation:
PMID:  8226494     Owner:  NLM     Status:  MEDLINE    
This study determined the effects of exercise on the ability of inflammatory macrophages to inhibit tumor cell growth in vitro (macrophage cytotoxicity). Thioglycollate injection (1 ml ip) was used as an inflammatory challenge and to partially activate macrophages for cytotoxicity. Inbred male C3H/HeN mice (n = 180) exercised moderately (MOD, 18 m/min, 30 min/day, 5% grade) or to exhaustion (EXH, 18-35 m/min, 2-4 h, 5% grade) on a motor-driven treadmill for 3 consecutive days after injection. Control (CON) mice were kept in stimulated treadmill lanes directly over the runners. Mice were killed immediately or 3 or 8 h postexercise. Macrophages from both MOD and EXH exercise groups manifested significantly (P < 0.05) enhanced (approximately 50%) cytotoxicity compared with those from CON group at all time points postexercise. This potentially beneficial exercise effect was not related to macrophage production of interleukin-1 beta, reactive nitrogen or oxygen intermediates, or number of macrophages in the assay but may have been manifested, in part, by tumor necrosis factor-alpha. Plasma corticosterone was significantly elevated immediately postexercise in MOD and EXH compared with CON mice; however, no evidence existed for an immuno-suppressive effect of corticosterone on macrophage cytotoxicity, perhaps because of insensitivity of inflammatory macrophages to glucocorticoid suppression seen in vitro. These data only partially support the "inverted U hypothesis," which states that moderate exercise may enhance, whereas very heavy exercise or a lack of exercise may attenuate, the immune response. Further study is needed to determine the physiological significance of these findings and the effects of exercise on macrophage subsets sensitive to glucocorticoid suppression (i.e., fully activated macrophages).
J A Woods; J M Davis; E P Mayer; A Ghaffar; R R Pate
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  75     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-03     Completed Date:  1993-12-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  879-86     Citation Subset:  IM    
Department of Exercise Science, School of Public Health, University of South Carolina, Columbia 29208.
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MeSH Terms
Arginine / analogs & derivatives,  pharmacology
Body Weight / physiology
Cell Survival / physiology
Cytotoxicity Tests, Immunologic
Cytotoxins / metabolism
Eating / physiology
Hydrocortisone / blood
Inflammation / immunology*
Leukocyte Count
Macrophages, Peritoneal / immunology,  physiology*
Mice, Inbred C3H
Neoplasms, Experimental / immunology*
Nitric Oxide / antagonists & inhibitors
Physical Conditioning, Animal*
Reg. No./Substance:
0/Cytotoxins; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 50-23-7/Hydrocortisone; 74-79-3/Arginine

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