Document Detail

Exercise increased BDNF and trkB in the contralateral hemisphere of the ischemic rat brain.
MedLine Citation:
PMID:  16054599     Owner:  NLM     Status:  MEDLINE    
Previous studies have suggested that brain-derived neurotrophic factor (BDNF) and trkB both have a role in plasticity following brain insults and exercise increases BDNF and trkB mRNA levels in the normal brain. We attempted to determine whether treadmill exercise improves motor function following experimental cerebral ischemia, and whether motor outcome is associated with BDNF and trkB expression. We subjected adult male Sprague-Dawley rats to a permanent ischemia, followed by either 12 days of treadmill exercise or non-exercise. In the exercise group, improvements in the motor behavior index were found and BDNF and trkB proteins in contralateral hemisphere were increased. This study suggests that after permanent brain ischemia, exercise improves motor performance and elevates BDNF and trkB proteins in the contralateral hemisphere.
Min-Wook Kim; Moon-Sug Bang; Tae-Ryoon Han; Young-Jin Ko; Byung-Woo Yoon; Jong-Hyun Kim; La-Mi Kang; Kyoung-Mi Lee; Man-Ho Kim
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  1052     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-09     Completed Date:  2005-10-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  16-21     Citation Subset:  IM    
Department of Rehabilitation Medicine, Our Lady of Mercy Hospital, College of Medicine, The Catholic University of Korea, 655 Bupyong-6-dong, Bypyong-ku, Incheon 403-720, Republic of Korea.
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MeSH Terms
Blotting, Western / methods
Brain / metabolism
Brain Ischemia / etiology,  metabolism,  rehabilitation*
Brain-Derived Neurotrophic Factor / metabolism*
Disease Models, Animal
Exercise Test / methods
Functional Laterality / physiology*
Gene Expression Regulation / physiology*
Immunohistochemistry / methods
Infarction, Middle Cerebral Artery / complications
Motor Activity / physiology
Physical Conditioning, Animal / physiology*
Rats, Sprague-Dawley
Receptor, trkB / metabolism*
Time Factors
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; EC, trkB

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