| Exercise in systemic sclerosis intensifies systemic inflammation and oxidative stress. | |
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MedLine Citation:
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PMID: 20132073 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Exercise testing can be used (i) to evaluate functional limitations of systemic sclerosis (SSc) and (ii) to study whether the inflammatory and oxidative systems are activated after a physical stimulus. The aim of this study was to determine exercise-induced inflammatory and oxidative responses in SSc compared with healthy subjects. METHODS: Eleven patients with SSc and pulmonary involvement and 10 healthy subjects underwent maximal cardiopulmonary exercise testing (CPET). Physiological responses were followed continuously during cycling. Blood samples were taken at rest, during and after maximal exercise to measure inflammatory and oxidative markers. RESULTS: In nine of the 11 SSc patients, cardiocirculatory limitation and gas exchange impairment limited exercise capacity. Basal inflammatory cells, interleukin (IL)-6, and oxidative stress were increased in SSc compared to healthy subjects and intensified after exercise. Basal and exercise-induced inflammation and oxidative stress were correlated with the modified Rodnan skin score. CONCLUSIONS: Although exercise capacity is impaired in patients with SSc, physical activity intensifies the already increased basal levels of systemic inflammation and oxidative stress. These data support the concept of a role for systemic inflammation and oxidative stress in the ongoing systemic effects of SSc. |
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Authors:
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H Hargard?ttir; H A C van Helvoort; M C Vonk; F H J van den Hoogen; P N R Dekhuijzen; Y F Heijdra |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Scandinavian journal of rheumatology Volume: 39 ISSN: 1502-7732 ISO Abbreviation: Scand. J. Rheumatol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-03-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0321213 Medline TA: Scand J Rheumatol Country: England |
Other Details:
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Languages: eng Pagination: 63-70 Citation Subset: IM |
Affiliation:
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Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Blood Chemical Analysis Case-Control Studies Exercise Test / methods* Exercise Tolerance / physiology Female Follow-Up Studies Forced Expiratory Volume Humans Inflammation Mediators / blood* Interleukin-6 / blood Leukocytosis / physiopathology Lipid Peroxidation / physiology Male Middle Aged Oxidative Stress / physiology Physical Endurance / physiology* Reactive Oxygen Species / blood* Reference Values Risk Assessment Scleroderma, Systemic / blood, diagnosis* Severity of Illness Index Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators; 0/Interleukin-6; 0/Reactive Oxygen Species |
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