Document Detail

Exercise in the community for people with minimal gait impairment due to MS: an assessor-blind randomized controlled trial.
MedLine Citation:
PMID:  23128667     Owner:  NLM     Status:  Publisher    
BACKGROUND: While there is an increasing body of evidence supporting the efficacy of exercise in people with multiple sclerosis (MS), additional information on the effectiveness of combining aerobic and resistance training, and yoga is required. OBJECTIVES: This study evaluated the effectiveness of community exercise interventions for people with MS having minimal gait impairment. METHODS: A multi-centred, block-randomised, assessor-blinded, controlled trial was conducted. Participants were randomised in groups of eight to physiotherapist (PT)-led exercise (n = 80), yoga (n = 77), fitness instructor (FI)-led exercise (n = 86) and they took part in weekly community-based group exercise sessions. Those in the control group were asked not to change of their exercise habits (n = 71). The primary outcome was the Multiple Sclerosis Impact Scale (MSIS) 29v2 physical component, measured before and after the 10-week intervention. Secondary outcomes were the MSIS 29v2 psychological component, the Modified Fatigue Impact Scale (MFIS) and the 6-Minute Walk Test (6MWT). RESULTS: The group x time interaction approached significance for the MSIS-29v2 physical component (f = 2.48, p = 0.061) and MFIS total (f = 2.50, p = 0.06), and it was significant for the MFIS physical subscale (f = 4.23, p = 0.006). All three exercise interventions led to a statistically significant improvement on the MSIS-29 psychological component and both the MFIS total and physical subscales, which were greater than the control (p < 0.05). Only the PT-led and FI-led interventions significantly improved the MSIS-29 physical and 6MWT to levels greater than the control (p < 0.05). CONCLUSIONS: This study provides evidence for the positive effect of exercise on the physical impact of MS and fatigue. The group nature of the classes may have contributed to the positive effects seen on the psychological impact of MS.
M Garrett; N Hogan; A Larkin; J Saunders; P Jakeman; S Coote
Related Documents :
7381717 - Effect of exercise on renal clearance of atenolol.
1756437 - Effect of prostaglandin inhibition by indomethacin on plasma active and inactive renin ...
24968127 - Reduced total and cause-specific mortality from walking and running in diabetes.
24809007 - Systemic cytokine response to three bouts of eccentric exercise.
1269497 - Methodological approaches to the study of the combined effect of atmospheric pollutants...
16287347 - Heart rate and blood lactate concentrations as predictors of physiological load on elit...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-5
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  -     ISSN:  1477-0970     ISO Abbreviation:  Mult. Scler.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Limerick, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pleiotropic effects of long-term monotherapy with rosuvastatin in dogs with moderate heart failure.
Next Document:  Acute disseminated encephalomyelitis followed by recurrent or monophasic optic neuritis in pediatric...