Document Detail

Exercise in closed-loop control: a major hurdle.
MedLine Citation:
PMID:  22226250     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: People with type 1 diabetes mellitus (T1DM) are at risk for exercise-induced hypoglycemia. Prevention of such hypoglycemia in a closed-loop setting is a major challenge. Markers for automated detection of physical activity could be heart rate (HR) and body acceleration counts (AC). Correlations between HR, AC, and glucose concentrations before and after moderate intensity exercise were examined in T1DM patients during open- loop control.
METHOD: Eleven T1DM subjects treated with an insulin pump performed moderate intensity exercise of 30 min. Glucose profiles, insulin concentrations, HR, and acceleration were measured.
RESULTS: Mean (range) glucose decrease during exercise was 1.4 (0 to 3.3) mmol/liter. The mean increase in HR was 45.2 beats per minutes (15 to 106 bpm). Mean increase in AC was 18,000 (3,000 to 25,000). No correlations were seen between the glucose drop and HR or AC. A trend was observed between the increase in HR and increase in AC.
CONCLUSION: Moderate intensity exercise resulted in increased HR and body AC while it decreased glucose concentrations but, in this real-time setting, no association could be demonstrated between the glucose decrease and increase in HR or AC.
Arianne C van Bon; Eugeny Verbitskiy; Golo von Basum; Joost B L Hoekstra; J Hans DeVries
Publication Detail:
Type:  Journal Article     Date:  2011-11-01
Journal Detail:
Title:  Journal of diabetes science and technology     Volume:  5     ISSN:  1932-2968     ISO Abbreviation:  J Diabetes Sci Technol     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-01-09     Completed Date:  2012-06-25     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101306166     Medline TA:  J Diabetes Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1337-41     Citation Subset:  IM    
Copyright Information:
© 2011 Diabetes Technology Society.
Academic Medical Center Amsterdam, The Netherlands.
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MeSH Terms
Blood Glucose / analysis*
Diabetes Mellitus, Type 1 / blood,  complications*,  drug therapy
Exercise / physiology*
Heart Rate / physiology*
Hypoglycemia / prevention & control*
Hypoglycemic Agents / administration & dosage
Insulin / administration & dosage
Insulin Infusion Systems
Middle Aged
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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