| Exercise in patients with intermittent claudication elicits signs of inflammation and angiogenesis. | |
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MedLine Citation:
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PMID: 19775917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Previous studies have demonstrated elevation of systemic levels of inflammatory cytokines after treadmill exercise in patients with intermittent claudication (IC), but it is unknown if growth factor expression also is stimulated. The aim of this study was to assess whether physical exercise-induced ischemia elicits an inflammatory response and increase in local and systemic vascular growth factor expression in patients with IC. METHODS: Nineteen patients with IC had plasma concentrations of inflammatory markers (IL-6, TNF-alpha, hs-CRP) and vascular growth factors (VEGF and FGF-2) measured before and at four time points after a treadmill exercise test. In 10 patients a gastrocnemius muscle biopsy was obtained to measure VEGF and FGF-2 mRNA. Plasma concentrations of vWF were also measured. Five patients who underwent the treadmill test without experiencing calf pain were enrolled as controls. RESULTS: Plasma concentrations of IL-6 increased after exercise (p=0.004), while TNF-alpha and hs-CRP were unchanged (p=0.191 and p=0.709, respectively). Plasma concentrations of VEGF were similar (p=0.151) at the different time points after exercise but FGF-2 levels decreased (p=0.013). In biopsies after treadmill testing VEGF-A mRNA was increased (p=0.043), but no change was observed for FGF-2 (p=0.456). CONCLUSION: Exercise in IC triggers an inflammatory response as exemplified by elevated concentrations of IL-6. After exercise-induced pain, VEGF mRNA in calf muscle is increased. Therefore, it is plausible that angiogenesis is stimulated by exercise in IC. |
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Authors:
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U Palmer-Kazen; P Religa; E Wahlberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-23 |
Journal Detail:
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Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 38 ISSN: 1532-2165 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-27 Completed Date: 2009-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: England |
Other Details:
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Languages: eng Pagination: 689-96 Citation Subset: IM |
Affiliation:
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Department of Molecular Medicine and Surgery, Vascular Biology Laboratory, Karolinska Institute, Stockholm, Sweden. ulrika.palmer-kazen@sodersjukhuset.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Markers / blood Biopsy C-Reactive Protein / metabolism Case-Control Studies Exercise* Exercise Test Female Fibroblast Growth Factor 2 / blood, genetics Humans Inflammation / blood, etiology*, physiopathology Inflammation Mediators / blood Interleukin-6 / blood Intermittent Claudication / blood, complications, physiopathology* Male Middle Aged Muscle, Skeletal / metabolism, physiopathology Neovascularization, Physiologic* RNA, Messenger / metabolism Tumor Necrosis Factor-alpha / blood Vascular Endothelial Growth Factor A / blood, genetics |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 103107-01-3/Fibroblast Growth Factor 2; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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