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Exercise improves global well-being in adults with fibromyalgia: confirmation of previous meta-analytic results using a recently developed and novel varying coefficient model.
MedLine Citation:
PMID:  22032521     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To determine the effects of exercise (aerobic, strength training or both) on global well-being in adults with fibromyalgia (FM). METHODS: The meta-analytic approach and recently developed varying coefficient model were used to pool the results of previous randomised controlled trials of exercise (aerobic, strength training or both) on global well-being in adults with FM. The standardised effect size (ES) for global well-being from each study was pooled using a recently developed and novel varying coefficient (VC) model and partitioned according to per-protocol and intention-to-treat analyses. Results were also compared to the traditionally used random effects (RE) model. Non-overlapping 95% confidence intervals were considered statistically significant with negative ESs indicative of improvements in global well-being. RESULTS: Five ESs representing 377 participants were included in the per-protocol analysis and 5 ESs representing 252 participants were included in the intention-to-treat analysis. Using the VC model, statistically significant improvements in global-well being were found for both per-protocol (-X, -0.39, 95% CI, -0.62, -0.15) and intention-to-treat analysis (-X, -0.40, 95% CI, -0.68, -0.13). Results were similar to those from the RE model. CONCLUSIONS: Using the recently developed and more valid varying coefficient model, these findings confirm that exercise improves global-well being in adults with FM.
Authors:
George A Kelley; Kristi S Kelley
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-27
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  -     ISSN:  0392-856X     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Community Medicine, West Virginia University, Morgantown, West Virginia, USA. gkelley@hsc.wvu.edu.
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