Document Detail

Exercise improves efficacy of levodopa in patients with Parkinson's disease.
MedLine Citation:
PMID:  17226855     Owner:  NLM     Status:  MEDLINE    
The objective was to investigate the impact of exercise on absorption and efficacy of levodopa (LD) in patients with Parkinson's disease (PD). A soluble, immediate release LD formulation was given followed by exercise near the aerobic limit on one day to PD patients, who underwent the same procedure only at rest on the second day. LD plasma behavior did not significantly differ between both conditions, but the motor response was significantly better 120 and 150 min after LD intake on the day with exercise than on the day with rest. Moderate exercise increases clinical efficacy of LD.
Siegfried Muhlack; Jacub Welnic; Dirk Woitalla; Thomas Müller
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  22     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-06     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-30     Citation Subset:  IM    
Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum 44791, Germany.
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MeSH Terms
Antiparkinson Agents / therapeutic use*
Area Under Curve
Levodopa / therapeutic use*
Middle Aged
Parkinsonian Disorders / blood,  therapy*
Severity of Illness Index
Time Factors
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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