| Exercise improves efficacy of levodopa in patients with Parkinson's disease. | |
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MedLine Citation:
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PMID: 17226855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective was to investigate the impact of exercise on absorption and efficacy of levodopa (LD) in patients with Parkinson's disease (PD). A soluble, immediate release LD formulation was given followed by exercise near the aerobic limit on one day to PD patients, who underwent the same procedure only at rest on the second day. LD plasma behavior did not significantly differ between both conditions, but the motor response was significantly better 120 and 150 min after LD intake on the day with exercise than on the day with rest. Moderate exercise increases clinical efficacy of LD. |
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Authors:
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Siegfried Muhlack; Jacub Welnic; Dirk Woitalla; Thomas Müller |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 22 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-03-06 Completed Date: 2007-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 427-30 Citation Subset: IM |
Affiliation:
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Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum 44791, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antiparkinson Agents / therapeutic use* Area Under Curve Exercise* Humans Levodopa / therapeutic use* Male Middle Aged Parkinsonian Disorders / blood, therapy* Severity of Illness Index Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Levodopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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