| Exercise improves body fat, lean mass, and bone mass in breast cancer survivors. | |
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MedLine Citation:
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PMID: 19629060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Given the negative effects of a breast cancer diagnosis and its treatments on body weight and bone mass, we investigated the effects of a 6-month randomized controlled aerobic exercise intervention vs. usual care on body composition in breast cancer survivors. Secondary aims were to examine the effects stratified by important prognostic and physiologic variables. Seventy-five physically inactive postmenopausal breast cancer survivors were recruited through the Yale-New Haven Hospital Tumor Registry and randomly assigned to an exercise (n = 37) or usual care (n = 38) group. The exercise group participated in 150 min/week of supervised gym- and home-based moderate-intensity aerobic exercise. The usual care group was instructed to maintain their current physical activity level. Body composition was assessed at baseline and 6-months through dual-energy X-ray absorptiometry (DXA) by one radiologist blinded to the intervention group of the participants. On an average, exercisers increased moderate-intensity aerobic exercise by 129 min/week over and above baseline levels compared with 45 min/week among usual care participants (P < 0.001). Exercisers experienced decreases in percent body fat (P = 0.0022) and increases in lean mass (P = 0.047) compared with increases in body fat and decreases in lean mass in usual care participants. Bone mineral density (BMD) was also maintained among exercisers compared with a loss among usual care participants (P = 0.043). In summary, moderate-intensity aerobic exercise, such as brisk walking, produces favorable changes in body composition that may improve breast cancer prognosis. |
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Authors:
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Melinda L Irwin; Marty Alvarez-Reeves; Lisa Cadmus; Eileen Mierzejewski; Susan T Mayne; Herbert Yu; Gina G Chung; Beth Jones; M Tish Knobf; Loretta DiPietro |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-02-19 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 17 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-28 Completed Date: 2009-10-08 Revised Date: 2012-04-10 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1534-41 Citation Subset: IM |
Affiliation:
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Yale School of Medicine, New Haven, Connecticut, USA. melinda.irwin@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adipose Tissue* Adult Aged Anthropometry / methods Body Composition Body Mass Index Bone Density / physiology* Breast Neoplasms / pathology*, therapy* Densitometry / methods Exercise / physiology* Female Humans Middle Aged Postmenopause |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000125-41S10028/RR/NCRR NIH HHS; M01-RR00125/RR/NCRR NIH HHS; R01 CA132931-04/CA/NCI NIH HHS; R01 CA138556-04/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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