Document Detail

Exercise improves bladder function in diabetic mice.
MedLine Citation:
PMID:  20860017     Owner:  NLM     Status:  In-Process    
AIMS: We determined the effect of exercise on bladder dysfunction and voiding frequency in db/db mice.
MATERIALS AND METHODS: Diabetic db/db female mice (BKS.Cg-Dock7m +/+ Leprdb/J strain) and their age-matched wild-type controls (WT) were equally divided into sedentary and exercise groups. Mice were exercised for 1 hr everyday for 8 weeks (speed of 5.2 m/min). We performed a voiding pattern test, cystometric analysis and reactivity of isolated bladder strips in WT and db/db mice, both sedentary and exercised.
RESULTS: Diabetes increased the frequency of voiding, bladder capacity, and residual volume. Exercise decreased voiding frequency in db/db mice; voiding frequency was 5.8 ± 0.5 (db/db exercise) versus 10.8 ± 1.1 (db/db control, P < 0.001). In cystometric analysis, the bladder capacity of db/db sedentary mice was 0.27 ± 0.05 ml and was 0.14 ± 0.02 ml in the db/db exercise group (P < 0.05), whereas the residual volume was 0.2 ± 0.03 ml in db/db sedentary mice and 0.06 ± 0.02 ml in db/db Ex mice. Isolated strips of bladder muscle from sedentary db/db mice were more responsive to carbachol than strips from db/db exercise mice. Exercise did not improve the urodynamic properties of WT mice, both sedentary and exercised.
CONCLUSIONS: Exercise improves bladder function in diabetic mice by reducing voiding frequency and improving urodynamic parameters.
Manasi Vadhavkar; Saeid Golbidi; Jason Sea; Michelle Longpre; Lynn Stothers; Ismail Laher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-21
Journal Detail:
Title:  Neurourology and urodynamics     Volume:  30     ISSN:  1520-6777     ISO Abbreviation:  Neurourol. Urodyn.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8303326     Medline TA:  Neurourol Urodyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
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