| Exercise improves bladder function in diabetic mice. | |
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MedLine Citation:
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PMID: 20860017 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIMS: We determined the effect of exercise on bladder dysfunction and voiding frequency in db/db mice. MATERIALS AND METHODS: Diabetic db/db female mice (BKS.Cg-Dock7m +/+ Leprdb/J strain) and their age-matched wild-type controls (WT) were equally divided into sedentary and exercise groups. Mice were exercised for 1 hr everyday for 8 weeks (speed of 5.2 m/min). We performed a voiding pattern test, cystometric analysis and reactivity of isolated bladder strips in WT and db/db mice, both sedentary and exercised. RESULTS: Diabetes increased the frequency of voiding, bladder capacity, and residual volume. Exercise decreased voiding frequency in db/db mice; voiding frequency was 5.8 ± 0.5 (db/db exercise) versus 10.8 ± 1.1 (db/db control, P < 0.001). In cystometric analysis, the bladder capacity of db/db sedentary mice was 0.27 ± 0.05 ml and was 0.14 ± 0.02 ml in the db/db exercise group (P < 0.05), whereas the residual volume was 0.2 ± 0.03 ml in db/db sedentary mice and 0.06 ± 0.02 ml in db/db Ex mice. Isolated strips of bladder muscle from sedentary db/db mice were more responsive to carbachol than strips from db/db exercise mice. Exercise did not improve the urodynamic properties of WT mice, both sedentary and exercised. CONCLUSIONS: Exercise improves bladder function in diabetic mice by reducing voiding frequency and improving urodynamic parameters. |
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Authors:
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Manasi Vadhavkar; Saeid Golbidi; Jason Sea; Michelle Longpre; Lynn Stothers; Ismail Laher |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-21 |
Journal Detail:
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Title: Neurourology and urodynamics Volume: 30 ISSN: 1520-6777 ISO Abbreviation: Neurourol. Urodyn. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303326 Medline TA: Neurourol Urodyn Country: United States |
Other Details:
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Languages: eng Pagination: 174-82 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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