| Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients. | |
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MedLine Citation:
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PMID: 17180156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether exercise augments the improvements in fractional synthetic rate (FSR) of albumin observed with nutrition alone. DESIGN: Randomized crossover study. Each patient randomly participated in two protein metabolism kinetic studies using primed-constant infusion of (13C) leucine 2 h before, during and 2 h after hemodialysis. Plasma enrichments of (13C) leucine and (13C) ketoisocaproate were examined to determine the FSR of albumin. SETTING: General Clinical Research Center at Vanderbilt University Medical Center. SUBJECTS: Five chronic hemodialysis (CHD) patients. INTERVENTIONS: Intra-dialytic parenteral nutrition (IDPN) with or without exercise. RESULTS: Exercise performance during hemodialysis significantly improves the FSR of albumin beyond what is observed with IDPN alone (26.2+/-3.1% per day versus 17.7+/-1.9% per day, P<0.05). CONCLUSION: Exercise improves albumin fractional synthetic rate beyond what is observed with IDPN alone in the acute setting in CHD patients. |
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Authors:
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L B Pupim; P J Flakoll; T A Ikizler |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-12-20 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 61 ISSN: 0954-3007 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-02 Completed Date: 2007-06-25 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 686-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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metabolism Caproates / pharmacokinetics* Carbon Isotopes Cross-Over Studies Exercise / physiology* Female Humans Kidney Failure, Chronic / blood, therapy* Leucine / pharmacokinetics* Male Middle Aged Parenteral Nutrition Renal Dialysis* Serum Albumin / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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DK-20593/DK/NIDDK NIH HHS; K24-DK62849/DK/NIDDK NIH HHS; M01 RR-00095/RR/NCRR NIH HHS; R01-DK45604/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Caproates; 0/Carbon Isotopes; 0/Serum Albumin; 61-90-5/Leucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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