Document Detail


Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation.
MedLine Citation:
PMID:  21198979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have evaluated the possibility that the action of voluntary exercise on the regulation of brain-derived neurotrophic factor (BDNF), a molecule important for rat hippocampal learning, could involve mechanisms of epigenetic regulation. We focused the studies on the Bdnf promoter IV, as this region is highly responsive to neuronal activity. We have found that exercise stimulates DNA demethylation in Bdnf promoter IV, and elevates levels of activated methyl-CpG-binding protein 2, as well as BDNF mRNA and protein in the rat hippocampus. Chromatin immunoprecipitation assay showed that exercise increases acetylation of histone H3, and protein assessment showed that exercise elevates the ratio of acetylated :total for histone H3 but had no effects on histone H4 levels. Exercise also reduces levels of the histone deacetylase 5 mRNA and protein implicated in the regulation of the Bdnf gene [N.M. Tsankova et al. (2006)Nat. Neurosci., 9, 519-525], but did not affect histone deacetylase 9. Exercise elevated the phosphorylated forms of calcium/calmodulin-dependent protein kinase II and cAMP response element binding protein, implicated in the pathways by which neural activity influences the epigenetic regulation of gene transcription, i.e. Bdnf. These results showing the influence of exercise on the remodeling of chromatin containing the Bdnf gene emphasize the importance of exercise on the control of gene transcription in the context of brain function and plasticity. Reported information about the impact of a behavior, inherently involved in the daily human routine, on the epigenome opens exciting new directions and therapeutic opportunities in the war against neurological and psychiatric disorders.
Authors:
F Gomez-Pinilla; Y Zhuang; J Feng; Z Ying; G Fan
Related Documents :
22556019 - Cerebral cortex oxygen delivery and exercise limitation in patients with copd.
7086339 - Oxygen uptake in air and water in the air-breathing reedfish calamoichthys calabaricus:...
3512509 - Estimation of volume of epithelial lining fluid recovered by lavage using urea as marke...
17894539 - Lung deposition of formoterol hfa (atimos/forair) in healthy volunteers, asthmatic and ...
1788489 - Changes in alveolar mixing efficiency during exercise.
2256739 - Relation between chest expansion, pulmonary function, and exercise tolerance in patient...
23392539 - Characteristics of spontaneous physical activity and executive functions in postmenopause.
2632139 - Computer linked apparatus for upper limb therapy: a new system of resistive exercise.
12957629 - 'in vitro' antioxidant and photoprotective properties and interaction with model membra...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-12-31
Journal Detail:
Title:  The European journal of neuroscience     Volume:  33     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-05-12     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  383-90     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Brain-Derived Neurotrophic Factor / biosynthesis,  genetics*
Chromatin Assembly and Disassembly / genetics
Chromatin Immunoprecipitation
DNA Methylation / genetics
Epigenesis, Genetic / genetics*
Gene Expression
Gene Expression Regulation / genetics
Hippocampus / physiology*
Male
Motor Activity / genetics
Neuronal Plasticity / genetics*
Physical Conditioning, Animal / physiology*
Promoter Regions, Genetic / genetics
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
NS50465/NS/NINDS NIH HHS; NS51411/NS/NINDS NIH HHS; NS56413/NS/NINDS NIH HHS; R01 NS050465/NS/NINDS NIH HHS; R01 NS050465-05/NS/NINDS NIH HHS; R01 NS056413/NS/NINDS NIH HHS; R01 NS056413-02/NS/NINDS NIH HHS; R01 NS056413-03/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Contribution of the mouse calyx of Held synapse to tone adaptation.
Next Document:  Enhanced brainstem encoding predicts musicians' perceptual advantages with pitch.