Document Detail

Exercise and haemostatic function.
MedLine Citation:
PMID:  8536150     Owner:  NLM     Status:  MEDLINE    
To reduce the risk of ischaemic heart disease, vigorous exercise has to be maintained over time. This suggests that the benefit is at least partly due to a short-term effect, such as an influence on the haemostatic system and thrombogenic potential. A high plasma fibrinogen level is strongly and independently associated with the incidence of ischaemic heart disease, and the effects of exercise on fibrinogen have now been extensively investigated. One randomized controlled trial and several large epidemiological studies show that vigorous exercise lowers the plasma fibrinogen level by an amount that would reduce the risk of ischaemic heart disease by 7 or 8% on a conservative estimate, along with additional benefits due to any favourable effects on blood pressure and lipids, for example. However, unaccustomed exertion raises the immediate risk of ischaemic heart disease probably, at least in part, through a short-term increase in coagulability. Thus, those who are not accustomed to physical exertion should approach it gradually in the early stages of exercise programmes.
T W Meade
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular risk     Volume:  2     ISSN:  1350-6277     ISO Abbreviation:  J Cardiovasc Risk     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-02-06     Completed Date:  1996-02-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9436980     Medline TA:  J Cardiovasc Risk     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  323-9     Citation Subset:  IM    
MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, Medical College, St Bartholomew's Hospital, London, UK.
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MeSH Terms
Coronary Disease / blood,  prevention & control
Fibrinogen / metabolism
Risk Factors
Reg. No./Substance:

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