| Exercise, fatigue, neurotransmission and the influence of the neuroendocrine axis. | |
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MedLine Citation:
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PMID: 15206769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fatigue during prolonged exercise has traditionally been attributed to the occurrence of a "metabolic end point", where muscle glycogen concentrations are depleted, plasma glucose concentrations are reduced, and plasma free fatty acid levels are elevated. But there exists also a "central fatigue hypothesis" which is based on the increase in the concentration of brain serotonin (5-Hydroxytryptamine or 5-HT) during exercise. However, the physiological mechanisms for central fatigue are largely unexplored, therefore we designed several experiments where central serotonergic activity was manipulated. These animal and human experiments showed that although brain neurotransmission had significantly increased, the supplementation with L-TRP did not lead to premature fatigue. In human studies we used several reuptake inhibitors in order to modify brain activity during exercise. These results clearly showed that time trial performance could not be influenced, but that during prolonged exercise the brain activity can be influenced, as measured by the peripheral hormones. |
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Authors:
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Romain Meeusen; Maria Francesca Piacentini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 527 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2003 |
Date Detail:
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Created Date: 2004-06-21 Completed Date: 2004-09-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 521-5 Citation Subset: IM |
Affiliation:
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Vrije Universiteit Brussel, Dept Human Physiology & Sportsmedicine--Pleinlaan 2 B1050 Brussels, Belgium. rmeeusen@vub.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, physiology Dopamine / physiology Fatigue / physiopathology* Humans Neurosecretory Systems / drug effects, physiology* Norepinephrine / physiology Physical Exertion / drug effects, physiology* Rats Serotonin / secretion Synaptic Transmission / drug effects, physiology* Tryptophan / pharmacology |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 51-41-2/Norepinephrine; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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