Document Detail

Exercise and exhaustion effects on glycogen synthesis pathways.
MedLine Citation:
PMID:  8941524     Owner:  NLM     Status:  MEDLINE    
Female Sprague-Dawley rats were infused with [1-13C]glucose to measure the effect of endurance training and the effect of various metabolic conditions on pathways of hepatic glycogen synthesis. Four metabolic states [sedentary (S), trained (T), sedentary exhausted (SE), and trained exhausted (TE)] were studied. T and TE rats were trained on a motor-driven treadmill (30 m/min, 15% grade, 1.0 h/day, 5 days/wk) for 8-10 wk. After a 24-h fast, SE and TE rats were run to exhaustion (sedentary average = 78 min, trained average = 155 min) at a training pace and immediately infused with labeled glucose for 2 h. S and T rats were infused after a 24-h fast. After infusion, tissues were removed and glycogen was isolated and hydrolyzed to glucose. The glucose was measured for distribution of 13C by using nuclear magnetic resonance. Glycogen was synthesized predominantly by the indirect pathway for all metabolic states, indicating that infused glucose was first metabolized primarily in the peripheral tissue. The direct-pathway utilization was greater in rested S than in rested T animals (30 vs. 14%); however, for exhausted animals, the trained use of the direct pathway was greater (22 vs. 9%). Both TE and rested T animals utilize the indirect pathway a comparable amount. Sedentary animals, on the other hand, dramatically decreased utilization of the direct pathway, with exhaustive exercise changing from 30 to 9%. The results indicate that endurance training modifies glucose utilization during glycogen synthesis after fasting and exhaustive exercise.
H Gunderson; N Wehmeyer; D Burnett; J Nauman; C Hartzell; S Savage
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  81     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-13     Completed Date:  1997-03-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2020-6     Citation Subset:  IM; S    
Chemistry Department, Northern Arizona University, Flagstaff 86011-5698, USA.
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MeSH Terms
Blood Glucose / metabolism
Glucose / administration & dosage,  metabolism
Infusions, Intravenous
Lactic Acid / blood
Liver Glycogen / biosynthesis*
Magnetic Resonance Spectroscopy
Muscle Fatigue / physiology*
Muscle, Skeletal / metabolism
Physical Conditioning, Animal
Physical Endurance / physiology
Physical Exertion / physiology*
Rats, Sprague-Dawley
Grant Support
1 R15 DK-41439-01/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Blood Glucose; 0/Liver Glycogen; 50-21-5/Lactic Acid; 50-99-7/Glucose

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