| Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹⁸F]fallypride. | |
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MedLine Citation:
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PMID: 20960487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [¹⁸F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [¹⁸F]fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training. |
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Authors:
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Marta G Vučković; Quanzheng Li; Beth Fisher; Angelo Nacca; Richard M Leahy; John P Walsh; Jogesh Mukherjee; Celia Williams; Michael W Jakowec; Giselle M Petzinger |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 25 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-17 Completed Date: 2011-04-08 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 2777-84 Citation Subset: IM |
Copyright Information:
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© 2010 Movement Disorder Society. |
Affiliation:
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Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Analysis of Variance Animals Benzamides Blotting, Western Corpus Striatum / metabolism*, physiopathology, radionuclide imaging Male Mice Mice, Inbred C57BL Neurons / metabolism* Parkinson Disease, Secondary / chemically induced, metabolism*, physiopathology, radionuclide imaging Physical Conditioning, Animal / physiology* Positron-Emission Tomography Pyrrolidines Receptors, Dopamine D2 / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS044327-01/NS/NINDS NIH HHS; R01 NS044327-02/NS/NINDS NIH HHS; R01 NS044327-03/NS/NINDS NIH HHS; R01 NS044327-04/NS/NINDS NIH HHS; R01 NS044327-05A2/NS/NINDS NIH HHS; R01 NS44327-1/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzamides; 0/N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide; 0/Pyrrolidines; 0/Receptors, Dopamine D2; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine |
| Comments/Corrections | |
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