Document Detail


Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹⁸F]fallypride.
MedLine Citation:
PMID:  20960487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [¹⁸F]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [¹⁸F]fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training.
Authors:
Marta G Vučković; Quanzheng Li; Beth Fisher; Angelo Nacca; Richard M Leahy; John P Walsh; Jogesh Mukherjee; Celia Williams; Michael W Jakowec; Giselle M Petzinger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  25     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-17     Completed Date:  2011-04-08     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2777-84     Citation Subset:  IM    
Copyright Information:
© 2010 Movement Disorder Society.
Affiliation:
Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Analysis of Variance
Animals
Benzamides
Blotting, Western
Corpus Striatum / metabolism*,  physiopathology,  radionuclide imaging
Male
Mice
Mice, Inbred C57BL
Neurons / metabolism*
Parkinson Disease, Secondary / chemically induced,  metabolism*,  physiopathology,  radionuclide imaging
Physical Conditioning, Animal / physiology*
Positron-Emission Tomography
Pyrrolidines
Receptors, Dopamine D2 / metabolism*
Grant Support
ID/Acronym/Agency:
R01 NS044327-01/NS/NINDS NIH HHS; R01 NS044327-02/NS/NINDS NIH HHS; R01 NS044327-03/NS/NINDS NIH HHS; R01 NS044327-04/NS/NINDS NIH HHS; R01 NS044327-05A2/NS/NINDS NIH HHS; R01 NS44327-1/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Benzamides; 0/N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide; 0/Pyrrolidines; 0/Receptors, Dopamine D2; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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