| Exercise electrocardiography detection of coronary artery disease by ST-segment depression/heart rate hysteresis in women: the Finnish Cardiovascular Study. | |
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MedLine Citation:
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PMID: 19068271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The performance of exercise electrocardiography (ECG) for the detection of coronary artery disease (CAD) in women has been limited. The recently developed computerized variable, ST-segment depression/heart rate (ST/HR) hysteresis, has been proved to detect CAD in men more accurately than traditional methods. However, the diagnostic performance of ST/HR hysteresis has not been evaluated in women. MATERIALS AND METHODS: The study population comprised 161 female patients from the Finnish Cardiovascular Study (FINCAVAS). All patients were referred for a routine bicycle exercise test. The maximum values of ST/HR hysteresis, ST/HR index, ST-segment depression at peak exercise (STpeak), at the end of one (ST1rec) and three (ST3rec) minutes of post-exercise were determined. Significant CAD was present in 48, while 65 women showed no angiographic CAD. Also a group of 48 women with low likelihood of CAD (LLC) was formed. Diagnostic performance of variables was assessed by receiver operating characteristic (ROC) analysis. Furthermore, sensitivity values at 80% specificity and specificities at 80% sensitivity were determined. RESULTS: In a comparison between CAD and LLC groups, the ROC areas for ST/HR hysteresis, ST/HR index, STpeak, ST1rec and ST3rec were 0.89, 0.74, 0.65, 0.84 and 0.73, and sensitivities at 80% specificity were 88%, 67%, 52%, 75% and 60%, respectively. Comparing CAD and no-CAD groups, the ROC areas were 0.73, 0.67, 0.56, 0.63 and 0.60, and specificities at 80% sensitivity were 60%, 38%, 27%, 33% and 30%. CONCLUSIONS: ST/HR hysteresis is a more competent method in CAD detection in women than ST-segment depression or ST/HR index. |
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Authors:
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Kati Svart; Rami Lehtinen; Tuomo Nieminen; Kjell Nikus; Terho Lehtimäki; Tiit Kööbi; Kari Niemelä; Mari Niemi; Väinö Turjanmaa; Mika Kähönen; Jari Viik |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2008-12-07 |
Journal Detail:
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Title: International journal of cardiology Volume: 140 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 182-8 Citation Subset: IM |
Copyright Information:
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Copyright 2008 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Biomedical Engineering, Tampere University of Technology, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cohort Studies Coronary Artery Disease / diagnosis*, epidemiology Diagnosis, Computer-Assisted / methods, standards Electrocardiography / methods*, standards* Exercise Test / methods*, standards* Female Finland / epidemiology Humans Middle Aged Prognosis ROC Curve Reproducibility of Results Risk Factors Sensitivity and Specificity Women's Health |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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