Document Detail


Exercise effects on activities of Na(+),K(+)-ATPase, acetylcholinesterase and adenine nucleotides hydrolysis in ovariectomized rats.
MedLine Citation:
PMID:  19748491     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hormone deficiency following ovariectomy causes activation of Na(+),K(+)-ATPase and acetylcholinesterase (AChE) that has been related to cognitive deficits in experimental animals. Considering that physical exercise presents neuroprotector effects, we decide to investigate whether exercise training would affect enzyme activation in hippocampus and cerebral cortex, as well as adenosine nucleotide hydrolysis in synaptosomes from cerebral cortex of ovariectomized rats. Female adult Wistar rats were assigned to one of the following groups: sham (submitted to surgery without removal of the ovaries), exercise, ovariectomized (Ovx) and Ovx plus exercise. Thirty days after surgery, animals were submitted to one month of exercise training, three times per week. After, rats were euthanized, blood serum was collected and hippocampus and cerebral cortex were dissected. Data demonstrated that exercise reversed the activation of Na(+),K(+)-ATPase and AChE activities both in hippocampus and cerebral cortex of ovariectomized rats. Ovariectomy decreased AMP hydrolysis in cerebral cortex and did not alter adenine nucleotides hydrolysis in blood serum. Exercise per se decreased ADP and AMP hydrolysis in cerebral cortex. On the other hand, AMP hydrolysis in blood serum was increased by exercise in ovariectomized adult rats. Present data support that physical exercise might have beneficial effects and constitute a therapeutic alternative to hormone replacement therapy for estrogen deprivation.
Authors:
Juliana Ben; Fl?via Mahatma Schneider Soares; Fernanda Cechetti; Fernanda Cenci Vuaden; Carla Denise Bonan; Carlos Alexandre Netto; Angela Terezinha de Souza Wyse
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-11
Journal Detail:
Title:  Brain research     Volume:  1302     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-06     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  248-55     Citation Subset:  IM    
Affiliation:
Laborat?rio de Neuroprote??o e Doen?a Metab?lica, Departamento de Bioqu?mica, Instituto de Ci?ncias B?sicas da Sa?de, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / metabolism*
Adenine Nucleotides / metabolism*
Adenosine Diphosphate / metabolism
Adenosine Monophosphate / metabolism
Animals
Biological Markers / analysis,  metabolism
Cerebral Cortex / anatomy & histology,  metabolism
Down-Regulation / physiology
Enzyme Activation / physiology
Estrogens / deficiency
Estrous Cycle / physiology
Female
Gonadal Steroid Hormones / metabolism,  secretion
Hippocampus / anatomy & histology,  metabolism
Hydrolysis
Ovariectomy
Ovary / metabolism,  secretion
Physical Conditioning, Animal / physiology*
Postmenopause / physiology
Presynaptic Terminals / metabolism
Prosencephalon / anatomy & histology,  metabolism*
Rats
Rats, Wistar
Sodium-Potassium-Exchanging ATPase / metabolism*
Chemical
Reg. No./Substance:
0/Adenine Nucleotides; 0/Biological Markers; 0/Estrogens; 0/Gonadal Steroid Hormones; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; EC 3.1.1.7/Acetylcholinesterase; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

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