| Exercise effect on oxidative stress is independent of change in estrogen metabolism. | |
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MedLine Citation:
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PMID: 18199727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The effect of exercise training on lipid peroxidation and endogenous estrogens is not well understood in premenopausal women. Exercise effects on these variables could mediate observed associations of exercise with hormonally related cancers, including breast cancer. The purpose of the study is to determine the effect of 15 weeks of aerobic exercise on lipid peroxidation, endogenous estrogens, and body composition in young, healthy eumenorrheic women. METHODS: Fifteen sedentary premenopausal women (18-25 years) participated. Pre- and post-exercise training urine collection (three 24-h samples) started 48 h after most recent exercise session for analysis of a marker of lipid peroxidation (F(2)-isoprostane) and endogenous estrogens, including 2-hydroxyestrogens, 4-hydroxyestrogens, 16-alpha-hydroxyestrone, and ratios of these metabolites (2:16, 2:4). Body composition was measured by dual-energy X-ray absorptiometry, and F(2)-isoprostanes and estrogens were measured by gas chromatography-mass spectrometry. RESULTS: Aerobic exercise resulted in a 34% decrease in F(2)-isoprostane (P = 0.02), a 10% increase in fitness (P = 0.004), a 1.2 kg decrease in body mass (P = 0.007), and a 1.8 kg decrease in fat mass (P = 0.04). No significant changes were noted in estrogens. CONCLUSIONS: The effect of exercise training on oxidative stress may be relevant to risk for hormonally related cancers. |
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Authors:
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Kathryn H Schmitz; Meghan Warren; Andrew G Rundle; Nancy I Williams; Myron D Gross; Mindy S Kurzer |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 17 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-17 Completed Date: 2008-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 220-3 Citation Subset: IM |
Affiliation:
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Division of Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA. schmitz@mail.med.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Estrogens / metabolism* Exercise / physiology* Female Gas Chromatography-Mass Spectrometry Humans Lipid Peroxidation Oxidative Stress / physiology* Postmenopause Premenopause |
| Grant Support | |
ID/Acronym/Agency:
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K07 CA 92348-01A1/CA/NCI NIH HHS; M01 RR 00400/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Estrogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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