| Exercise echocardiography in rheumatoid arthritis: a case-control study. | |
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MedLine Citation:
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PMID: 19782532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Rheumatoid arthritis (RA) is associated with increased cardiovascular risk. METHODS: To assess the role of exercise echocardiography (EE) in the evaluation of patients with RA, follow-up (mean, 6.7+/-3.7 years) was retrospectively obtained in 159 patients with RA who underwent EE. Patients were matched for age, gender, and cardiovascular risk factors with 454 controls who underwent EE. RESULTS: Patients with RA were more likely to have positive results for ischemia on EE (odds ratio, 2.32; 95% confidence interval, 1.48-3.64; P=.0003). Rest and exercise wall motion score indexes were higher in the RA group (1.14+/-0.33 and 1.22+/-0.39, respectively, vs 1.06+/-0.18 and 1.10+/-0.24 in controls; P < .005 for each). Logistic regression adjusted for age revealed an increased odds ratio for myocardial ischemia of 1.06 (95% confidence interval, 1.02-1.11; P=.005) per year of RA. Five-year all-cause mortality in subjects with RA with myocardial ischemia on EE was 14.9%, compared with 4.3% in RA subjects without ischemia (P=.028). CONCLUSION: RA was associated with a 2-fold increased risk for myocardial ischemia on EE; risk increased with the duration of RA. Mortality was increased in patients with RA with ischemia on EE. |
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Authors:
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Mohammed K Saghir; Christine Attenhofer Jost; Kenneth J Warrington; Stephen S Cha; Patricia A Pellikka |
Publication Detail:
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Type: Journal Article Date: 2009-09-25 |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 22 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-03 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 1228-31 Citation Subset: IM |
Affiliation:
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Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arthritis, Rheumatoid / physiopathology* Case-Control Studies Coronary Angiography Echocardiography, Stress / methods* Female Humans Logistic Models Male Middle Aged Myocardial Ischemia / mortality, physiopathology*, ultrasonography* Retrospective Studies Risk Factors Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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