Document Detail

Exercise echocardiography in rheumatoid arthritis: a case-control study.
MedLine Citation:
PMID:  19782532     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Rheumatoid arthritis (RA) is associated with increased cardiovascular risk. METHODS: To assess the role of exercise echocardiography (EE) in the evaluation of patients with RA, follow-up (mean, 6.7+/-3.7 years) was retrospectively obtained in 159 patients with RA who underwent EE. Patients were matched for age, gender, and cardiovascular risk factors with 454 controls who underwent EE. RESULTS: Patients with RA were more likely to have positive results for ischemia on EE (odds ratio, 2.32; 95% confidence interval, 1.48-3.64; P=.0003). Rest and exercise wall motion score indexes were higher in the RA group (1.14+/-0.33 and 1.22+/-0.39, respectively, vs 1.06+/-0.18 and 1.10+/-0.24 in controls; P < .005 for each). Logistic regression adjusted for age revealed an increased odds ratio for myocardial ischemia of 1.06 (95% confidence interval, 1.02-1.11; P=.005) per year of RA. Five-year all-cause mortality in subjects with RA with myocardial ischemia on EE was 14.9%, compared with 4.3% in RA subjects without ischemia (P=.028). CONCLUSION: RA was associated with a 2-fold increased risk for myocardial ischemia on EE; risk increased with the duration of RA. Mortality was increased in patients with RA with ischemia on EE.
Mohammed K Saghir; Christine Attenhofer Jost; Kenneth J Warrington; Stephen S Cha; Patricia A Pellikka
Publication Detail:
Type:  Journal Article     Date:  2009-09-25
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  22     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-03     Completed Date:  2010-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1228-31     Citation Subset:  IM    
Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Arthritis, Rheumatoid / physiopathology*
Case-Control Studies
Coronary Angiography
Echocardiography, Stress / methods*
Logistic Models
Middle Aged
Myocardial Ischemia / mortality,  physiopathology*,  ultrasonography*
Retrospective Studies
Risk Factors
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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