Document Detail

Exercise duration as a determinant of vascular function and antioxidant balance in patients with coronary artery disease.
MedLine Citation:
PMID:  21357374     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Exercise improves the clinical outcome of patients with coronary artery disease (CAD); however, the ideal exercise duration for each patient remains unclear.
OBJECTIVE: To investigate the effects of exercise duration on arterial elastic properties and antioxidant/pro-oxidant mechanisms in patients with CAD.
DESIGN, SETTING, PATIENTS, INTERVENTIONS: Sixty male patients with CAD were randomised into two groups, and underwent exercise for 30 min or 60 min in a crossover design with 2 weeks' wash-out period. In all participants aortic and radial blood pressures (BP) and arterial elastic properties (augmentation index (AIx)/pulse wave velocity (PWV)) were determined at baseline and 24 h after exercise. Plasma malonyldialdehyde (MDA) and superoxide dismutase (SOD)1 and SOD2 levels were also measured.
RESULTS: Exercise had no effect on aortic and radial BP (p=NS for all). Walking for 30 min improved AIx (from 33.79 ± 0.91% to 31.73 ± 0.86%, p<0.001) and PWV (from 9.26 ± 0.95 m/s to 9.06 ± 0.21 m/s, p<0.001), while exercise for 60 min had adverse effects on vascular stiffness (for AIx: from 33.37 ± 0.93% to 33.73 ± 1.05%, p=NS and for PWV: from 9.25 ± 0.19 m/s to 9.37 ± 0.21 m/s, p < 0.05 mainly in older patients). Exercise for 60 min was associated with a significant 20% increase in MDA levels (p<0.05). Exercise had no effects on SOD1 levels, however it significantly increased SOD2 levels after 30 min (from 2.26 ± 0.22 ng/mL to 2.36 ± 0.18 ng/mL, p < 0.05) but not after 60 min (p=NS). Conclusion Shorter exercise duration was associated with favourable antioxidant and vascular effects, while longer exercise blunted these beneficial effects and was accompanied by adverse effects on vascular function, mainly in older coronary patients. Further studies are required to explore the hypothesis that a more individualised approach to the selection of the appropriate exercise programme should be considered for patients with CAD.
A P Michaelides; D Soulis; C Antoniades; A S Antonopoulos; A Miliou; N Ioakeimidis; E Chatzistamatiou; C Bakogiannis; K Marinou; C Liakos; C Stefanadis
Related Documents :
17984944 - Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sede...
25483984 - Mercury analysis in hair: comparability and quality assessment within the transnational...
16095404 - Acute hormonal responses to submaximal and maximal heavy resistance and explosive exerc...
19430944 - Hormonal and metabolic responses to slow movement resistance exercise with different du...
12358134 - Antihypertensive effects of aerobic exercise in middle-aged normotensive men with exagg...
3133964 - Double-blind crossover study comparing sodium cromoglycate, reproterol, reproterol plus...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-02-25
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  97     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-25     Completed Date:  2011-07-01     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  832-7     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / metabolism*
Blood Flow Velocity / physiology
Coronary Artery Disease / physiopathology*,  therapy
Cross-Over Studies
Elasticity / physiology
Exercise / physiology*
Exercise Therapy / methods
Malondialdehyde / metabolism
Middle Aged
Superoxide Dismutase / metabolism
Vascular Resistance / physiology
Walking / physiology
Reg. No./Substance:
0/Antioxidants; 4Y8F71G49Q/Malondialdehyde; EC 1.15.1.-/superoxide dismutase 1; EC Dismutase; EC dismutase 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fractalkine in human inflammatory cardiomyopathy.
Next Document:  Diagnostic accuracy of echocardiography for pulmonary hypertension: a systematic review and meta-ana...