Document Detail


Exercise duration as a determinant of vascular function and antioxidant balance in patients with coronary artery disease.
MedLine Citation:
PMID:  21357374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Exercise improves the clinical outcome of patients with coronary artery disease (CAD); however, the ideal exercise duration for each patient remains unclear.
OBJECTIVE: To investigate the effects of exercise duration on arterial elastic properties and antioxidant/pro-oxidant mechanisms in patients with CAD.
DESIGN, SETTING, PATIENTS, INTERVENTIONS: Sixty male patients with CAD were randomised into two groups, and underwent exercise for 30 min or 60 min in a crossover design with 2 weeks' wash-out period. In all participants aortic and radial blood pressures (BP) and arterial elastic properties (augmentation index (AIx)/pulse wave velocity (PWV)) were determined at baseline and 24 h after exercise. Plasma malonyldialdehyde (MDA) and superoxide dismutase (SOD)1 and SOD2 levels were also measured.
RESULTS: Exercise had no effect on aortic and radial BP (p=NS for all). Walking for 30 min improved AIx (from 33.79 ± 0.91% to 31.73 ± 0.86%, p<0.001) and PWV (from 9.26 ± 0.95 m/s to 9.06 ± 0.21 m/s, p<0.001), while exercise for 60 min had adverse effects on vascular stiffness (for AIx: from 33.37 ± 0.93% to 33.73 ± 1.05%, p=NS and for PWV: from 9.25 ± 0.19 m/s to 9.37 ± 0.21 m/s, p < 0.05 mainly in older patients). Exercise for 60 min was associated with a significant 20% increase in MDA levels (p<0.05). Exercise had no effects on SOD1 levels, however it significantly increased SOD2 levels after 30 min (from 2.26 ± 0.22 ng/mL to 2.36 ± 0.18 ng/mL, p < 0.05) but not after 60 min (p=NS). Conclusion Shorter exercise duration was associated with favourable antioxidant and vascular effects, while longer exercise blunted these beneficial effects and was accompanied by adverse effects on vascular function, mainly in older coronary patients. Further studies are required to explore the hypothesis that a more individualised approach to the selection of the appropriate exercise programme should be considered for patients with CAD.
Authors:
A P Michaelides; D Soulis; C Antoniades; A S Antonopoulos; A Miliou; N Ioakeimidis; E Chatzistamatiou; C Bakogiannis; K Marinou; C Liakos; C Stefanadis
Related Documents :
672544 - Hormonal and metabolic responses to exercise in subject of high and low work capacities.
11090564 - Bioassayable growth hormone release in rats in response to a single bout of treadmill e...
23881334 - Is eccentric exercise an effective treatment for lateral epicondylitis? a systematic re...
19088784 - Time course alterations of plasma obestatin and growth hormone levels in response to sh...
12705654 - Setting the stage: developmental biology in pre-college classrooms.
15546334 - A 10-year follow-up study of pulmonary function in symptomatic elite cross-country skie...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-02-25
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  97     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-25     Completed Date:  2011-07-01     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  832-7     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Antioxidants / metabolism*
Blood Flow Velocity / physiology
Coronary Artery Disease / physiopathology*,  therapy
Cross-Over Studies
Elasticity / physiology
Exercise / physiology*
Exercise Therapy / methods
Humans
Male
Malondialdehyde / metabolism
Middle Aged
Superoxide Dismutase / metabolism
Vascular Resistance / physiology
Walking / physiology
Chemical
Reg. No./Substance:
0/Antioxidants; 4Y8F71G49Q/Malondialdehyde; EC 1.15.1.-/superoxide dismutase 1; EC 1.15.1.1/Superoxide Dismutase; EC 1.15.1.1/superoxide dismutase 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fractalkine in human inflammatory cardiomyopathy.
Next Document:  Diagnostic accuracy of echocardiography for pulmonary hypertension: a systematic review and meta-ana...