| Exercise and duchenne muscular dystrophy: Toward evidence-based exercise prescription. | |
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MedLine Citation:
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PMID: 21404285 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To develop a rational framework for answering questions about the role of exercise in Duchenne muscular dystrophy (DMD), we focused on five pathophysiological mechanisms and offer brief hypotheses regarding how exercise may beneficially modulate pertinent cellular and molecular pathways. We aimed to provide an integrative overview of mechanisms of DMD pathology that may improve or worsen as a result of exercise. We also sought to stimulate discussion of what outcomes/dependent variables most appropriately measure these mechanisms, with the purpose of defining criteria for well-designed, controlled studies of exercise in DMD. The five mechanisms include pathways that are both intrinsic and extrinsic to the diseased muscle cells. Muscle Nerve 43: 464-478, 2011. |
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Authors:
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Chad D Markert; Fabrisia Ambrosio; Jarrod A Call; Robert W Grange |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 43 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 464-78 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA. cmarkert@wfubmc.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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