Document Detail


Exercise and duchenne muscular dystrophy: Toward evidence-based exercise prescription.
MedLine Citation:
PMID:  21404285     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
To develop a rational framework for answering questions about the role of exercise in Duchenne muscular dystrophy (DMD), we focused on five pathophysiological mechanisms and offer brief hypotheses regarding how exercise may beneficially modulate pertinent cellular and molecular pathways. We aimed to provide an integrative overview of mechanisms of DMD pathology that may improve or worsen as a result of exercise. We also sought to stimulate discussion of what outcomes/dependent variables most appropriately measure these mechanisms, with the purpose of defining criteria for well-designed, controlled studies of exercise in DMD. The five mechanisms include pathways that are both intrinsic and extrinsic to the diseased muscle cells. Muscle Nerve 43: 464-478, 2011.
Authors:
Chad D Markert; Fabrisia Ambrosio; Jarrod A Call; Robert W Grange
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  43     ISSN:  1097-4598     ISO Abbreviation:  Muscle Nerve     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  464-78     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Wake Forest Institute for Regenerative Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA. cmarkert@wfubmc.edu.
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