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Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis?
MedLine Citation:
PMID:  22435073     Owner:  NLM     Status:  PubMed-not-MEDLINE    
It has been suggested that exercise (or physical activity) might have the potential to have an impact on multiple sclerosis (MS) pathology and thereby slow down the disease process in MS patients. The objective of this literature review was to identify the literature linking physical exercise (or activity) and MS disease progression. A systematic literature search was conducted in the following databases: PubMed, SweMed+, Embase, Cochrane Library, PEDro, SPORTDiscus and ISI Web of Science. Different methodological approaches to the problem have been applied including (1) longitudinal exercise studies evaluating the effects on clinical outcome measures, (2) cross-sectional studies evaluating the relationship between fitness status and MRI findings, (3) cross-sectional and longitudinal studies evaluating the relationship between exercise/physical activity and disability/relapse rate and, finally, (4) longitudinal exercise studies applying the experimental autoimmune encephalomyelitis (EAE) animal model of MS. Data from intervention studies evaluating disease progression by clinical measures (1) do not support a disease-modifying effect of exercise; however, MRI data (2), patient-reported data (3) and data from the EAE model (4) indicate a possible disease-modifying effect of exercise, but the strength of the evidence limits definite conclusions. It was concluded that some evidence supports the possibility of a disease-modifying potential of exercise (or physical activity) in MS patients, but future studies using better methodologies are needed to confirm this.
Ulrik Dalgas; Egon Stenager
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic advances in neurological disorders     Volume:  5     ISSN:  1756-2864     ISO Abbreviation:  Ther Adv Neurol Disord     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-21     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101480242     Medline TA:  Ther Adv Neurol Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  81-95     Citation Subset:  -    
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