Document Detail


Exercise and diet modification in nonobese nonalcoholic fatty liver disease; analysis of biopsies of living liver donors.
MedLine Citation:
PMID:  22554085     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background/Aims:  We evaluated efficacy of exercise and diet modification for steatosis improvement of nonobese nonalcoholic fatty liver disease (NAFLD) patients. Methods:  We analyzed retrospectively the clinical and histological parameters of consecutive living liver donors, who experienced repeated liver biopsies due to steatosis and were treated using exercise and diet modification. Results:  From 1995 to 2009, among a total of 1,365 potential living liver donors with NAFLD seen on the initial liver biopsy, 120 consecutive donors with steatosis ≥30% or an estimated donor-recipient weight ratio <0.8, underwent exercise and diet modification and received follow-up liver biopsy at our institution. Median age was 33 years, and median interval between the two consecutive biopsies was 10 weeks (range, 1-39). At the time of initial biopsy, the number of normal body mass index, overweight, and obese donors was 49 (40.8%), 65 (54.2%), and 6 (5.0%), respectively. After lifestyle modification, weight reduction and steatosis improvement were observed in 92 (76.7%) and 103 (85.8%) donors, respectively, at the time of follow-up biopsy. On multivariate analysis, initially higher steatosis (hazard ratio [HR] 1.03, P=0.02), total cholesterol reduction ≥10% (HR 5.59, P=0.02), and weight reduction ≥5% (HR 6.63, P=0.03) were significantly associated with ≥20% steatosis improvement in 120 donors with NAFLD, after exercise and diet modification. Conclusions:  Exercise and diet modification were effective in reducing steatosis in potential living liver donors with nonobese NAFLD. Total cholesterol reduction ≥10% could be used as a noninvasive predictor for steatosis improvement in liver donors with NAFLD, after exercise and diet modification. © 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Authors:
Young-Joo Jin; Kang Mo Kim; Shin Hwang; Sung Gyu Lee; Tae-Yong Ha; Gi-Won Song; Dong-Hwan Jung; Ki-Hun Kim; Eunsil Yu; Ju Hyun Shim; Young-Suk Lim; Han Chu Lee; Young-Hwa Chung; Yungsang Lee; Dong-Jin Suh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-3
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Internal Medicine, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
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