Document Detail


Exercise and diet-induced weight loss attenuates oxidative stress related-coronary vasoconstriction in obese adolescents.
MedLine Citation:
PMID:  22814577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is a disease of oxidative stress (OS). Acute hyperoxia (breathing 100 % O(2)) can evoke coronary vasoconstriction by the oxidative quenching of nitric oxide (NO). To examine if weight loss would alter the hyperoxia-related coronary constriction seen in obese adolescents, we measured the coronary blood flow velocity (CBV) response to hyperoxia using transthoracic Doppler echocardiography before and after a 4-week diet and exercise regimen in 6 obese male adolescents (age 13-17 years, BMI 36.5 ± 2.3 kg/m(2)). Six controls of similar age and BMI were also studied. The intervention group lost 9 ± 1 % body weight, which was associated with a reduced resting heart rate (HR), reduced diastolic blood pressure (BP), and reduced RPP (all P < 0.05). Before weight loss, hyperoxia reduced CBV by 33 ± 3 %. After weight loss, CBV only fell by 15 ± 3 % (P < 0.05). In the control group, CBV responses to hyperoxia were unchanged during the two trials. Thus weight loss: (1) reduces HR, BP, and RPP; and (2) attenuates the OS-related coronary constrictor response seen in obese adolescents. We postulate that: (1) the high RPP before weight loss led to higher myocardial O(2) consumption, higher coronary flow and greater NO production, and in turn a large constrictor response to hyperoxia; and (2) weight loss decreased myocardial oxygen demand and NO levels. Under these circumstances, hyperoxia-induced vasoconstriction was attenuated.
Authors:
Zhaohui Gao; Marsha Novick; Matthew D Muller; Ronald J Williams; Samson Spilk; Urs A Leuenberger; Lawrence I Sinoway
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-20
Journal Detail:
Title:  European journal of applied physiology     Volume:  113     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-08-01     Revised Date:  2014-05-26    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  519-28     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Flow Velocity
Combined Modality Therapy / methods
Coronary Circulation*
Coronary Stenosis / etiology,  physiopathology*,  rehabilitation*
Coronary Vessels / physiopathology
Diet Therapy / methods*
Exercise Therapy / methods*
Humans
Male
Obesity / complications,  physiopathology*,  rehabilitation*
Oxidative Stress
Treatment Outcome
Vasoconstriction
Grant Support
ID/Acronym/Agency:
C06 RR016499/RR/NCRR NIH HHS; M01 RR010732/RR/NCRR NIH HHS; M01 RR010732/RR/NCRR NIH HHS; R01 HL070222/HL/NHLBI NIH HHS; R01 HL070222/HL/NHLBI NIH HHS; UL1 TR000127/TR/NCATS NIH HHS
Comments/Corrections

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