Document Detail

Exercise and diastolic function after myocardial infarction.
MedLine Citation:
PMID:  12972864     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study was to determine the effects of exercise training on LV geometry and LV diastolic function in a rat model of MI. METHODS: One month after MI induced by ligation of the left anterior descending artery (N = 45) or sham operation (N = 26), rats were randomized to either a sedentary or exercise group. Exercise consisted of treadmill running at 24 m.min-1, 1 h.d-1, 5 d.wk-1, for 3 wk. Passive LV pressure volume relationships were established with an isolated, red-cell-perfused Langendorff preparation. Infarct size was determined histologically and categorized as small (<30% of LV) or large (> or =30% of LV). RESULTS: LV end-diastolic pressure-volume relationships were shifted rightward with increasing infarct size (P < 0.05). Exercise training further shifted the LV end-diastolic pressure-volume relationships rightward in sham, small MI and large MI (P < 0.05). Peak LV developed pressure was comparable in sedentary and exercised-trained hearts in sham, small MI, and large MI. LV diameter and septal wall thickness were greatest in large MI (P < 0.05). Exercise-trained hearts showed a tendency for a greater LV diameter and septal wall thickness in sham, small MI, and large MI. Scar thinning was most notable in large MI (P < 0.05). CONCLUSION: Moderate-intensity treadmill running induces myocardial remodeling and a rightward shift in the LV end-diastolic pressure-volume relationship after MI, an adaptation similar to what is observed with exercise training in sham hearts without MI.
Joseph R Libonati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  35     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-15     Completed Date:  2004-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1471-6     Citation Subset:  IM; S    
Department of Kinesiology, Temple University, Philadelphia, PA 19003, USA.
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MeSH Terms
Disease Models, Animal
Exercise Therapy*
Myocardial Infarction / rehabilitation*,  veterinary
Rats, Wistar
Treatment Outcome
Ventricular Function, Left*
Ventricular Remodeling*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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