| Exercise and diastolic function after myocardial infarction. | |
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MedLine Citation:
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PMID: 12972864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to determine the effects of exercise training on LV geometry and LV diastolic function in a rat model of MI. METHODS: One month after MI induced by ligation of the left anterior descending artery (N = 45) or sham operation (N = 26), rats were randomized to either a sedentary or exercise group. Exercise consisted of treadmill running at 24 m.min-1, 1 h.d-1, 5 d.wk-1, for 3 wk. Passive LV pressure volume relationships were established with an isolated, red-cell-perfused Langendorff preparation. Infarct size was determined histologically and categorized as small (<30% of LV) or large (> or =30% of LV). RESULTS: LV end-diastolic pressure-volume relationships were shifted rightward with increasing infarct size (P < 0.05). Exercise training further shifted the LV end-diastolic pressure-volume relationships rightward in sham, small MI and large MI (P < 0.05). Peak LV developed pressure was comparable in sedentary and exercised-trained hearts in sham, small MI, and large MI. LV diameter and septal wall thickness were greatest in large MI (P < 0.05). Exercise-trained hearts showed a tendency for a greater LV diameter and septal wall thickness in sham, small MI, and large MI. Scar thinning was most notable in large MI (P < 0.05). CONCLUSION: Moderate-intensity treadmill running induces myocardial remodeling and a rightward shift in the LV end-diastolic pressure-volume relationship after MI, an adaptation similar to what is observed with exercise training in sham hearts without MI. |
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Authors:
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Joseph R Libonati |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 35 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-15 Completed Date: 2004-01-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 1471-6 Citation Subset: IM; S |
Affiliation:
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Department of Kinesiology, Temple University, Philadelphia, PA 19003, USA. jlibonat@astro.temple.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diastole Disease Models, Animal Exercise Therapy* Humans Male Myocardial Infarction / rehabilitation*, veterinary Rats Rats, Wistar Running Treatment Outcome Ventricular Function, Left* Ventricular Remodeling* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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