Document Detail

Exercise, depletion of antioxidants and antioxidant manipulation.
MedLine Citation:
PMID:  9857489     Owner:  NLM     Status:  MEDLINE    
Strenuous physical activity is known to increase the production of reactive oxygen species (ROS), associated with depletion of antioxidant defence. In the present work we evaluated the level of lipid peroxidation and antioxidant components in blood of sportsmen under resting conditions and compared the data obtained with those in age- and sex-matched sedentary controls. A significant increase was noted in the levels of thiobarbituric acid reactive substances (TBARS) and conjugated dienes while a decrease was observed in ascorbic acid and glutathione levels in sportsmen. alpha-Tocopherol was unaltered in plasma of sportsmen as compared to controls. The activity of superoxide dismutase was increased (52 per cent) and glutathione peroxidase was decreased (43 per cent) in the erythrocytes of sportsmen compared to controls. Basal glutathione levels were negatively correlated with conjugated dienes and maximal oxygen uptake (VO2max) of the subjects. Dietary supplementation with antioxidant vitamins has been shown to be beneficial in combating oxidative stress without enhancing performance while exogenous glutathione was found to influence the endurance capacity of athletes. Such studies demonstrate the critical role played by glutathione and suggest that intervention trials should include a mixture of antioxidants rather than a single antioxidant.
S D Balakrishnan; C V Anuradha
Related Documents :
22382039 - Intermittent maximal exercise improves attentional performance only in physically activ...
12380009 - The post-exercise oxidative stress is depressed by acetylsalicylic acid.
17851919 - Protective effect of edaravone against endolymphatic hydrops.
12957629 - 'in vitro' antioxidant and photoprotective properties and interaction with model membra...
10231349 - Influence of structurally different lipid emulsions on human neutrophil oxygen radical ...
16644199 - Interaction of vitamin e and exercise training on oxidative stress and antioxidant enzy...
21905269 - Exhaled breath temperature and exercise-induced bronchoconstriction in asthmatic children.
17369459 - Modulation of the spontaneous beat-to-beat fluctuations in peripheral vascular resistan...
1773809 - The influence of dietary manipulation on plasma ammonia accumulation during incremental...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biochemistry and function     Volume:  16     ISSN:  0263-6484     ISO Abbreviation:  Cell Biochem. Funct.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-02-08     Completed Date:  1999-02-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8305874     Medline TA:  Cell Biochem Funct     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  269-75     Citation Subset:  IM    
Department of Biochemistry, Annamalai University, Tamil Nadu, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / administration & dosage,  metabolism*
Ascorbic Acid / blood
Catalase / blood
Ceruloplasmin / analysis
Free Radical Scavengers
Glutathione / blood
Glutathione Peroxidase / blood
Lipid Peroxidation
Oxidative Stress
Physical Exertion*
Reactive Oxygen Species
Superoxide Dismutase / blood
Thiobarbituric Acid Reactive Substances / analysis
Vitamin E / blood
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 0/Thiobarbituric Acid Reactive Substances; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; EC; EC Peroxidase; EC Dismutase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oxidative activity in mitochondria isolated from rat liver at different stages of development.
Next Document:  Alteration of phosphotyrosine-containing proteins during differentiation of chicken erythroleukemia ...