Document Detail


Exercise, depletion of antioxidants and antioxidant manipulation.
MedLine Citation:
PMID:  9857489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Strenuous physical activity is known to increase the production of reactive oxygen species (ROS), associated with depletion of antioxidant defence. In the present work we evaluated the level of lipid peroxidation and antioxidant components in blood of sportsmen under resting conditions and compared the data obtained with those in age- and sex-matched sedentary controls. A significant increase was noted in the levels of thiobarbituric acid reactive substances (TBARS) and conjugated dienes while a decrease was observed in ascorbic acid and glutathione levels in sportsmen. alpha-Tocopherol was unaltered in plasma of sportsmen as compared to controls. The activity of superoxide dismutase was increased (52 per cent) and glutathione peroxidase was decreased (43 per cent) in the erythrocytes of sportsmen compared to controls. Basal glutathione levels were negatively correlated with conjugated dienes and maximal oxygen uptake (VO2max) of the subjects. Dietary supplementation with antioxidant vitamins has been shown to be beneficial in combating oxidative stress without enhancing performance while exogenous glutathione was found to influence the endurance capacity of athletes. Such studies demonstrate the critical role played by glutathione and suggest that intervention trials should include a mixture of antioxidants rather than a single antioxidant.
Authors:
S D Balakrishnan; C V Anuradha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biochemistry and function     Volume:  16     ISSN:  0263-6484     ISO Abbreviation:  Cell Biochem. Funct.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-02-08     Completed Date:  1999-02-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8305874     Medline TA:  Cell Biochem Funct     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  269-75     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Annamalai University, Tamil Nadu, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / administration & dosage,  metabolism*
Ascorbic Acid / blood
Catalase / blood
Ceruloplasmin / analysis
Diet
Free Radical Scavengers
Glutathione / blood
Glutathione Peroxidase / blood
Humans
Lipid Peroxidation
Male
Oxidative Stress
Physical Exertion*
Reactive Oxygen Species
Sports*
Superoxide Dismutase / blood
Thiobarbituric Acid Reactive Substances / analysis
Vitamin E / blood
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; 0/Thiobarbituric Acid Reactive Substances; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.16.3.1/Ceruloplasmin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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