Document Detail

Exercise and the coronary circulation-alterations and adaptations in coronary artery disease.
MedLine Citation:
PMID:  16517248     Owner:  NLM     Status:  MEDLINE    
Coronary vasorelaxation depends on nitric oxide (NO) bioavailability, which is a function of endothelial nitric oxide synthase-derived NO production and NO inactivation by reactive oxygen species. This fine-tuned balance is disrupted in coronary artery disease (CAD). The impairment of NO production in conjunction with excessive oxidative stress promotes the loss of endothelial cells by apoptosis, leads to a further aggravation of endothelial dysfunction and triggers myocardial ischemia in CAD. In healthy individuals, increased release of NO from the vasculature in response to exercise training results from changes in endothelial nitric oxide synthase expression, phosphorylation, and conformation. However, exercise training has assumed a role in cardiac rehabilitation of patients with CAD, as well, because it reduces mortality and increases myocardial perfusion. This has been largely attributed to exercise training-mediated correction of coronary endothelial dysfunction in CAD. Indeed, regular physical activity restores the balance between NO production and NO inactivation by reactive oxygen species in CAD, thereby enhancing the vasodilatory capacity in different vascular beds. Because endothelial dysfunction has been identified as a predictor of cardiovascular events, the partial reversal of endothelial dysfunction secondary to exercise training might be the most likely mechanism responsible for the exercise training-induced reduction in cardiovascular morbidity and mortality in patients with CAD.
Axel Linke; Sandra Erbs; Rainer Hambrecht
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  48     ISSN:  0033-0620     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-84     Citation Subset:  AIM; IM    
Department of Cardiology, University of Leipzig-Heart Center, Leipzig, Germany.
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MeSH Terms
Coronary Artery Disease / diagnosis,  mortality,  therapy*
Coronary Circulation / physiology*
Endothelium, Vascular / pathology*
Exercise / physiology*
Nitric Oxide / analysis,  metabolism*
Reactive Oxygen Species / metabolism
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Survival Analysis
Treatment Outcome
Vasodilation / physiology
Reg. No./Substance:
0/Reactive Oxygen Species; 10102-43-9/Nitric Oxide

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